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Functional and cognitive outcomes after COVID-19 delirium

2020; Elsevier BV; Volume: 11; Issue: 5 Linguagem: Inglês

10.1007/s41999-020-00353-8

1878-7657

Benjamin C. Mcloughlin, Amy Miles, Thomas E. Webb, Paul Knopp, Clodagh Eyres, Ambra Fabbri, Fiona Humphries, Daniel Davis,

Anesthesia and Sedative Agents

To ascertain delirium prevalence and outcomes in COVID-19.We conducted a point-prevalence study in a cohort of COVID-19 inpatients at University College Hospital. Delirium was defined by DSM-IV criteria. The primary outcome was all-cause mortality at 4 weeks; secondary outcomes were physical and cognitive function.In 71 patients (mean age 61, 75% men), 31 (42%) had delirium, of which only 12 (39%) had been recognised by the clinical team. At 4 weeks, 20 (28%) had died, 26 (36%) were interviewed by telephone and 21 (30%) remained as inpatients. Physical function was substantially worse in people after delirium - 50 out of 166 points (95% CI - 83 to - 17, p = 0.01). Mean cognitive scores at follow-up were similar and delirium was not associated with mortality in this sample.Our findings indicate that delirium is common, yet under-recognised. Delirium is associated with functional impairments in the medium term.