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In Vitro Antimicrobial, Antiviral and Cytotoxicity Activities of Aspergillus oryzae Isolated From El-Baida Marsh in Algeria

2020; Society of Pharmaceutical Tecnocrats; Volume: 10; Issue: 4 Linguagem: Inglês

10.22270/jddt.v10i4.4261

2250-1177

Nacef Houda Sara, Rachid Belhattab, Galvez Julio, Rodriguez-Sojo María Jesus, Teresa Vezza,

Fungal Biology and Applications

This work covers the study of antimicrobial and antiviral activities of the Aspergillus oryzae strain isolated from saline soil (El-Baida marsh in Algeria). The crude extract obtained with ethyl acetate displayed antimicrobial activity against Gram-positive and Gram-negative bacteria and the yeast Candida albicans with a mean of 16.69 mm of inhibition zone and a minimal inhibitory concentrations MICs between 7.28 and 21.85 μgmL-1. We also assessed the antiviral activity against Herpes simplex-2 Virus (HSV-2), in which no inhibitory effect was exhibited. In addition, cytotoxicity activity was tested in Caco-2 and RAW 264, a human epithelial and a murine macrophage cell line, respectively, revealing a no-toxic effect of the extract. The studied isolate extract possesses an antimicrobial property and its non-toxicity to the host cells becomes very important, and can be exploited for the production of new pharmacological and biotechnological agents. Keywords: Aspergillus oryzae, antimicrobial activity, antiviral activity, cytotoxicity, fungal extraction.