Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells
2020; Cell Press; Volume: 182; Issue: 3 Linguagem: Inglês
10.1016/j.cell.2020.06.031
ISSN1097-4172
AutoresYulia Shwartz, Meryem Gonzalez-Celeiro, Chih-Lung Chen, H. Amalia Pasolli, Shu‐Hsien Sheu, Sabrina Mai‐Yi Fan, Farnaz Shamsi, Steven Assaad, Edrick Tai-Yu Lin, Bing Zhang, Pai-Chi Tsai, Megan He, Yu‐Hua Tseng, Sung‐Jan Lin, Ya-Chieh Hsu,
Tópico(s)Wnt/β-catenin signaling in development and cancer
ResumoPiloerection (goosebumps) requires concerted actions of the hair follicle, the arrector pili muscle (APM), and the sympathetic nerve, providing a model to study interactions across epithelium, mesenchyme, and nerves. Here, we show that APMs and sympathetic nerves form a dual-component niche to modulate hair follicle stem cell (HFSC) activity. Sympathetic nerves form synapse-like structures with HFSCs and regulate HFSCs through norepinephrine, whereas APMs maintain sympathetic innervation to HFSCs. Without norepinephrine signaling, HFSCs enter deep quiescence by down-regulating the cell cycle and metabolism while up-regulating quiescence regulators Foxp1 and Fgf18. During development, HFSC progeny secretes Sonic Hedgehog (SHH) to direct the formation of this APM-sympathetic nerve niche, which in turn controls hair follicle regeneration in adults. Our results reveal a reciprocal interdependence between a regenerative tissue and its niche at different stages and demonstrate sympathetic nerves can modulate stem cells through synapse-like connections and neurotransmitters to couple tissue production with demands.
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