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General Cu-Catalyzed C sp –S Coupling

2020; American Chemical Society; Volume: 22; Issue: 15 Linguagem: Inglês

10.1021/acs.orglett.0c02004

1523-7060

Éric Godin, Jeffrey Santandrea, Antoine Caron, Shawn K. Collins,

Click Chemistry and Applications

Copper-catalyzed cross-coupling of thiols and bromoalkynes affords a mild, rapid, and selective Csp–S coupling with broad scope, enabling the use of aryl-, alkyl-, and silyl-substituted alkynyl coupling partners (38 total examples, 50–99% yields). Importantly, the method enables the preparation of difficult-to-access bis-heteroatom-functionalized (S,S-, S,P-, and S,N-) alkynes.