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Distinct clinical and immunological features of SARS–CoV-2–induced multisystem inflammatory syndrome in children

2020; American Society for Clinical Investigation; Volume: 130; Issue: 11 Linguagem: Inglês

10.1172/jci141113

1558-8238

Pui Y. Lee, Megan Day‐Lewis, Lauren A. Henderson, Kevin G. Friedman, Jeffrey Lo, Jordan E. Roberts, Mindy S. Lo, Craig D. Platt, Janet Chou, Kacie J. Hoyt, Annette Baker, Tina Banzon, Margaret H. Chang, Ezra M. Cohen, Sarah D. de Ferranti, Audrey Dionne, Saddiq B. Habiballah, Olha Halyabar, Jonathan S. Hausmann, Melissa M. Hazen, Erin Janssen, Esra Meidan, Ryan Nelson, Alan A. Nguyen, Robert P. Sundel, Fatma Dedeoğlu, Peter A. Nigrović, Jane W. Newburger, Mary Beth F. Son,

Inflammasome and immune disorders

BACKGROUND. Pediatric SARS–CoV-2 infection can be complicated by a dangerous hyperinflammatory condition termed multisystem inflammatory syndrome in children (MIS-C). The clinical and immunologic spectrum of MIS-C and its relationship to other inflammatory conditions of childhood have not been studied in detail.