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Organ-on-chip model shows that ATP release through connexin hemichannels drives spontaneous Ca 2+ signaling in non-sensory cells of the greater epithelial ridge in the developing cochlea

2020; Royal Society of Chemistry; Volume: 20; Issue: 16 Linguagem: Inglês

10.1039/d0lc00427h

1473-0197

Flavia Mazzarda, Annunziata D’Elia, Roberto Massari, Adele De Ninno, Francesca Romana Bertani, Luca Businaro, Gaia Ziraldo, Veronica Zorzi, Chiara Nardin, Chiara Peres, Francesco Chiani, Abraham Tettey‐Matey, Marcello Raspa, Ferdinando Scavizzi, A. Soluri, Anna Maria Salvatore, Jun Yang, Fabio Mammano,

Neuroscience and Neuropharmacology Research

Using microfluidics, ATP biosensors, multiphoton microscopy and genetically targeted mice, we show that ATP release through connexin hemichannels, and not pannexin 1 channels, underlies spontaneous Ca 2+ wave propagation in the greater epithelial ridge of the developing cochlea.