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Assessment of hematologic indices and their correlation to hemoglobin A1c among Bosnian children with type 1 diabetes mellitus and their healthy peers

2020; De Gruyter; Volume: 40; Issue: 2 Linguagem: Croata

10.5937/jomb0-25315

1452-8258

Suzana Tihić-Kapidžić, Adlija Čaušević, Jasmina Fočo-Solak, Maja Malenica, Tanja Dujić, Sniježana Hasanbegović, Nermina Babić, Ermin Begović,

Diabetes, Cardiovascular Risks, and Lipoproteins

Altered levels of many hematological parameters have been directly associated with diabetes in adults, while studies on children with type 1 diabetes mellitus are lacking. The aim of this study was to determine hematological indices in diabetic Bosnian children in comparison to healthy controls as well as to correlate their levels to blood glucose and hemoglobin A1c.100 healthy and 100 children with type 1 diabetes mellitus (age 1-18) were included in this study. Complete blood count, hemoglobin A1c, and glucose were tested. Results were analysed by IBM SPSS Statistics version 23.Significant differences (p<0.05) between healthy and diabetic children were found in relation to HbA1c, glucose, mean platelet volume, the number of white blood cells and erythrocytes, hematocrit, hemoglobin and MCH values. No gender differences or significant age differences were seen for hemoglobin, hematocrit, and MCV, while platelets, MPV, and MCH differed by age only in healthy children. When diabetic children were classified according to HbA1c levels, significant differences were seen for erythrocyte count and hematocrit value (p=0.013 and 0.019, respectively). The number of erythrocytes and white blood cells correlated significantly with HbA1c (p=0.037 and 0.027, respectively).Lower levels of erythrocytes, hematocrit, and hemoglobin in diabetic compared to healthy children indicate possible development of anemia, while higher MCV, MCH, and MPV values indicate an alteration in erythrocyte morphology. Hematological indices could be a useful inexpensive tool in the diagnosis and follow up of type 1 diabetes in children.Brojne studije ukazuju na promene hematološkog statusa kod odrasle populacije sa dijabetesom, dok su istraživanja na deci sa tipom 1 dijabetes melitusa nedovoljna. Cilj ovog istraživanja je bio utvrditi hematološki status kod dijabetične bosanske dece i uporediti ga sa zdravom kontrolnom grupom te analizirati vezu hematoloških parametara sa koncentracijama glukoze i hemoglobina A1c u serumu.U istraživanje je uključeno 100 zdrave i 100 dece sa tipom 1 dijabetes melitusa, starosti od 1 do 18 godina. Kompletna krvna slika, hemoglobin A1c i glukoza su testirani kod sve dece. Analiza podataka je urađena pomoću programa IBM SPSS Statistics, verzija 23.Značajne razlike (p<0,05) između zdrave i dijabetične dece su uočene u vrednostima HbA1c, glukoze, MPV, broju leukocita i eritrocita, hematokrita, hemoglobina i MCH. Polne razlike u vrednostima ispitivanih parametara nisu nađene. Starosne razlike su bile značajne za vrednosti hemoglobina, hematokrita i MCV. Broj trombocita, MPV i MCH su pokazali starosne razlike samo kod zdrave dece. Podela dijabetične dece prema vrednostima HbA1c je pokazala da postoje značajne razlike samo u broju eritrocita i vrednosti hematokrita (p=0,013 i 0,019, respektivno). Broj eritrocita i leukocita je pokazao statistički značajne pozitivne korelacije sa HbA1c (p=0,037 i 0,027, respektivno).Niže vrednosti eritrocita, hematokrita i hemoglobina kod dijabetične u odnosu na zdravu decu indiciraju potencijalni razvoj anemije, dok više vrednosti MCV, MCH i MPV ukazuju na morfološke promene eritrocita. Hematološki parametri mogu biti jeftini i korisni pokazatelji u dijagnozi i praćenju dece sa tipom 1 dijabetes melitusa.