Portal de Periódicos da CAPES

Synthesis, Characterization, and Biologic Activity of New Acyl Hydrazides and 1,3,4-Oxadiazole Derivatives

2020; Multidisciplinary Digital Publishing Institute; Volume: 25; Issue: 14 Linguagem: Inglês

10.3390/molecules25143308

1433-1373

Irina Zarafu, Lilia Matei, Coralia Bleoţu, Petre Ioniță, Arnaud Tatibouët, Anca Păun, Ioana Nicolau, Anamaria Hanganu, Carmen Limban, Diana Camelia Nuță, Roxana Maria Nemeş, Carmen C. Diaconu, Cristiana Rădulescu,

Synthesis and Biological Evaluation

Starting from isoniazid and carboxylic acids as precursors, thirteen new hydrazides and 1,3,4-oxadiazoles of 2-(4-substituted-phenoxymethyl)-benzoic acids were synthesized and characterized by appropriate means. Their biological properties were evaluated in terms of apoptosis, cell cycle blocking, and drug metabolism gene expression on HCT-8 and HT-29 cell lines. In vitro antimicrobial tests were performed by the microplate Alamar Blue assay for the anti-mycobacterial activities and an adapted agar disk diffusion technique for other non-tubercular bacterial strains. The best antibacterial activity (anti-