Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases
2020; Frontiers Media; Volume: 11; Linguagem: Inglês
10.3389/fimmu.2020.01467
ISSN1664-3224
AutoresSamanta C. Funes, Mariana Ríos, Ayleen Fernández‐Fierro, Camila Covián, Susan M. Bueno, Claudia A. Riedel, Juan Pablo Mackern‐Oberti, Alexis M. Kalergis,
Tópico(s)Climate Change and Health Impacts
ResumoHeme-oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. A major anti-inflammatory role has been assigned to the HO-1 activity. Therefore, in recent years HO-1 induction has been employed as an approach to treating several disorders displaying some immune alterations components, such as exacerbated inflammation or self-reactivity. Many natural compounds have shown to be effective inductors of HO-1 without cytotoxic effects; among them, most are chemicals present in plants used as food, flavoring, and medicine. Here we discuss some naturally derived compounds involved in HO-1 induction, their impact in the immune response modulation, and the beneficial effect in diverse autoimmune disorders. We conclude that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle towards promoting human health. This review opens a new outlook on the investigation of naturally derived HO-1 inducers, mainly concerning to autoimmunity.
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