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Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination

2020; American Association for the Advancement of Science; Volume: 12; Issue: 553 Linguagem: Inglês

10.1126/scitranslmed.abb4757

1946-6242

Todd J. Suscovich, Jonathan K. Fallon, Jishnu Das, Allison Demas, Jonathan A. Crain, Caitlyn Linde, Ashlin R. Michell, Harini Natarajan, Claudia P. Arevalo, Thomas Broge, Thomas C. Linnekin, Viraj Kulkarni, Richard Lu, Matthew D. Slein, Corinne Luedemann, Meghan Marquette, Sandra March, Joshua A. Weiner, Scott Gregory, Margherita Coccia, Yevel Flores-García, Fidel Zavala, Margaret E. Ackerman, Elke S. Bergmann‐Leitner, Jenny Hendriks, Jerald Sadoff, Sheetij Dutta, Sangeeta N. Bhatia, Douglas A. Lauffenburger, Erik Jongert, Ulrike Wille-Reece, Galit Alter,

Complement system in diseases

A combination of two Fc antibody features that leverage innate immune function predicts protection from malaria challenge after RTS,S/AS01 vaccination.