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Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study

2020; Elsevier BV; Volume: 8; Issue: 9 Linguagem: Inglês

10.1016/s2213-8587(20)30218-7

2213-8595

Irina Bancos, Angela E. Taylor, Vasileios Chortis, Alice Sitch, Carl Jenkinson, Caroline Davidge‐Pitts, Katharina Lang, Stylianos Tsagarakis, Magdalena Macech, Anna Riester, Timo Deutschbein, Ivana D Pupovac, Tina Kienitz, Alessandro Prete, Thomas Papathomas, Lorna C Gilligan, Cristian Bancos, Giuseppe Reimondo, Magalie Haissaguerre, Ljiljana Marina, Marianne Aardal Grytaas, Ahmed Sajwani, Katharina Langton, Hannah E Ivison, Cedric Shackleton, Dana Erickson, Miriam Asia, Sotiria Palimeri, Agnieszka Kondracka, Ariadni Spyroglou, Cristina L. Ronchi, Bojana Simunov, Danae A. Delivanis, Robert P. Sutcliffe, Ioanna Tsirou, Tomasz Bednarczuk, Martín Reincke, Stephanie Burger‐Stritt, Richard A. Feelders, Letizia Canu, Harm R. Haak, Graeme Eisenhofer, Michael Conall Dennedy, Grethe Åstrøm Ueland, Miomira Ivović, Antoine Tabarin, Massimo Terzolo, Marcus Quinkler, Darko Kaštelan, Martin Faßnacht, Felix Beuschlein, Urszula Ambroziak, Dimitra A. Vassiliadi, Michael O’Reilly, William F. Young, Michael Biehl, Jonathan J Deeks, Wiebke Arlt, Stephan Glöckner, Richard Sinnott, Anthony Stell, Maria Candida Barisson Villares Fragoso, Darko Kaštelan, Ivana D. Pupovac, Bojana Simunov, Sarah Cazenave, Magalie Haissaguerre, Antoine Tabarin, Jérôme Bertherat, Rossella Libé, Tina Kienitz, Marcus Quinkler, Katharina Langton, Graeme Eisenhofer, Felix Beuschlein, Christina Brugger, Martín Reincke, Anna Riester, Ariadni Spyroglou, Stephanie Burger‐Stritt, Timo Deutschbein, Martin Faßnacht, Stefanie Hahner, Matthias Kroiß, Cristina L. Ronchi, Sotiria Palimeri, Stylianos Tsagarakis, Ioanna Tsirou, Dimitra A. Vassiliadi, Vittoria Basile, Elisa Ingargiola, Giuseppe Reimondo, Massimo Terzolo, Letizia Canu, Massimo Mannelli, Hester Ettaieb, Harm R. Haak, Thomas Kerkhofs, Michael Biehl, Richard A. Feelders, Johannes Hofland, Leo J. Hofland, Marianne Aardal Grytaas, Eystein S. Husebye, Grethe Åstrøm Ueland, Urszula Ambroziak, Tomasz Bednarczuk, Agnieszka Kondracka, Magdalena Macech, Malgorzata Zawierucha, Isabel Paiva, Michael Conall Dennedy, Ahmed Sajwani, Mark Sherlock, Rachel Crowley, Miomira Ivović, Ljiljana Marina, Jonathan J Deeks, Alice Sitch, Wiebke Arlt, Irina Bancos, Vasileios Chortis, Lorna C. Giligan, Beverly Hughes, Katharina Lang, Hannah E Ivison, Carl Jenkinson, Konstantinos Manolopoulos, Donna O’Neil, Michael O’Reilly, Thomas Papathomas, Alessandro Prete, Cedric Shackleton, Angela E. Taylor, Miriam Asia, Robert P. Sutcliffe, Peter Guest, Kassiani Skordilis, Cristian Bancos, Alice Y. Chang, Caroline Davidge‐Pitts, Danae A. Delivanis, Dana Erickson, Neena Natt, Todd B. Nippoldt, Melinda Thomas, William F. Young,

Cancer, Hypoxia, and Metabolism

Cross-sectional imaging regularly results in incidental discovery of adrenal tumours, requiring exclusion of adrenocortical carcinoma (ACC). However, differentiation is hampered by poor specificity of imaging characteristics. We aimed to validate a urine steroid metabolomics approach, using steroid profiling as the diagnostic basis for ACC.