Catalytic Asymmetric Transfer Hydrogenation of trans -Chalcone Derivatives Using BINOL-derived Boro-phosphates
2020; American Chemical Society; Volume: 22; Issue: 15 Linguagem: Inglês
10.1021/acs.orglett.0c02042
ISSN1523-7060
AutoresFei Na, Susana S. Lopez, Alice Beauseigneur, Lucas W. Hernandez, Zhuoxin Sun, Jon C. Antilla,
Tópico(s)Organoboron and organosilicon chemistry
ResumoChiral phosphoric-acid-catalyzed asymmetric reductions of trans-chalcones have been investigated in this work. A BINOL-derived boro-phosphate-catalyzed asymmetric transfer hydrogenation of the carbon-carbon double bond of trans-chalcone derivatives employing borane as a hydride source was realized. This methodology provides a convenient procedure to access chiral dihydrochalone derivatives in high yields and with high enantioselectivities under mild conditions.
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