Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Structural characterization, electronic properties, and anxiolytic-like effect in adult zebrafish (Danio rerio) of cinnamaldehyde chalcone

2020; Elsevier BV; Volume: 1222; Linguagem: Inglês

10.1016/j.molstruc.2020.128954

1872-8014

Jayze da Cunha Xavier, Francisco Wagner Queiroz Almeida-Neto, Priscila Teixeira da Silva, Emmanuel Silva Marinho, Maria Kueirislene Amâncio Ferreira, Francisco Ernani Alves Magalhães, C.E.S. Nogueira, Paulo Nogueira Bandeira, Jane Eire Silva Alencar de Menezes, Alexandre Magno Rodrigues Teixeira, Hélcio Silva dos Santos,

Nonlinear Optical Materials Research

Zebrafish is a model animal that is used for neurobehavioral studies. It is an excellent model organism for pharmacological studies and/or safety research at an early stage of drug development. In this work, the chalcone (2E, 4E)-1-(2‑hydroxy-3,4,6-trimethoxyphenyl)-5-phenylpenta-2,4‑dien‑1-one, was synthesized by the Claisen-Schmidt condensation from two natural products: 2‑hydroxy-3,4,6-trimethoxyacetophenone and cinnamaldehyde. The molecular structure of this compound was confirmed by spectroscopic methods such as NMR, Infrared, UV–vis, and quantum chemical calculations. In addition, the anxiolytic-like effect of the cinnamaldehyde chalcone in adult zebrafish (Danio rerio) was evaluated. The results showed that chalcone caused an approximately 80% reduction in zebrafish locomotor activity and induced maximum permanence of zebrafish in the clear zone (61.16%) at a dose of 0.5 mg kgl−1. The data suggest that the cinnamaldehyde chalcone has anxiolytic activity.