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Geriatric nutritional risk index as a prognostic marker of pTNM-stage I and II esophageal squamous cell carcinoma after curative resection

2020; Impact Journals LLC; Volume: 11; Issue: 29 Linguagem: Inglês

10.18632/oncotarget.27670

1949-2553

Noriyuki Hirahara, Takeshi Matsubara, Yusuke Fujii, Shunsuke Kaji, Ryoji Hyakudomi, Tetsu Yamamoto, Yuki Uchida, Yoshiko Miyazaki, Kazunari Ishitobi, Yasunari Kawabata, Yoshitsugu Tajima,

Esophageal and GI Pathology

// Noriyuki Hirahara 1 , Takeshi Matsubara 1 , Yusuke Fujii 1 , Shunsuke Kaji 1 , Ryoji Hyakudomi 1 , Tetsu Yamamoto 1 , Yuki Uchida 1 , Yoshiko Miyazaki 1 , Kazunari Ishitobi 1 , Yasunari Kawabata 1 and Yoshitsugu Tajima 1 1 Department of Digestive and General Surgery, Shimane University Faculty of Medicine, Izumo, Shimane 693-8501, Japan Correspondence to: Noriyuki Hirahara, email: norinorihirahara@yahoo.co.jp Keywords: geriatric nutritional risk index; esophageal squamous cell carcinoma; curative esophagectomy; cancer-specific survival; pathological tumor-node-metastasis Received: May 09, 2020 Accepted: June 20, 2020 Published: July 21, 2020 ABSTRACT The geriatric nutritional risk index (GNRI) is associated with mortality in several malignancies. We retrospectively analyzed whether the GNRI can predict long-term outcomes in 191 patients with esophageal squamous cell carcinoma (ESCC) after curative esophagectomies by evaluating their cancer-specific survival (CSS). In multivariate analyses, serum albumin (hazard ratio [HR], 2.498; p = 0.0043), GNRI (HR, 1.941; p = 0.0181), pathological tumor-node-metastasis (pTNM) stage (HR, 3.884; p < 0.0001), and tumor differentiation (HR, 2.307; p = 0.0066) were independent prognostic factors for CSS. In pTNM stage I, multivariate analysis identified C-reactive protein (HR, 7.172; p = 0.0483) and GNRI (HR, 5.579; p = 0.0291) as independent prognostic factors for CSS. In univariate analyses in pTNM stages II and III, only low GNRI ( p = 0.0095) and low serum albumin levels ( p = 0.0119), respectively, were significantly associated with worse CSS. In patients with low GNRI, CSS was significantly worse than in those with normal GNRI ( p = 0.0011), especially in pTNM stages I ( p = 0.0044) and II ( p = 0.0036) groups, but not in stage III group ( p = 0.5099). Preoperative GNRI may sort patients into low- or high-risk groups for shorter CSS, especially in those with pTNM stage I and II ESCC.