Produção Nacional
Revisado por pares
In situ photocrosslinkable formulation of nanocomposites based on multi-walled carbon nanotubes and formononetin for potential application in spinal cord injury treatment
2020; Elsevier BV; Volume: 29; Linguagem: Inglês
10.1016/j.nano.2020.102272
ISSN1549-9642
AutoresAlessa Caroline Pedroza de Vasconcelos, Renata Pinho Morais, Gabrielle Barrozo Novais, Sheilla da Silva Barroso, Luana Renyelle Oliveira Menezes, Stefane dos Santos, Luiz Pereira da Costa, Cristiane Bani Corrêa, Patrícia Severino, Margarete Zanardo Gomes, Ricardo Luiz Cavalcanti de Albuquerque Júnior, Juliana Cordeiro Cardoso,
Tópico(s)Electrospun Nanofibers in Biomedical Applications
ResumoCarbon nanotubes (CN) have been studied to treat spinal cord injuries because of its electrical properties and nanometric dimensions. This work aims to develop a photopolymerizable hydrogel containing CN functionalized with an anti-inflammatory molecule to be used in situ on spinal cord injuries. The CN functionalization step was done using the drug (formononetin). The nanocomposites were characterized by morphological analysis, FTIR, Raman Spectroscopy, thermal analysis and cytotoxicity assays (MTT and HET-CAM). The nanocomposites were incorporated into gelatin methacryloyl hydrogel and exposed to UV light for photopolymerization. The volume of the formulation and the UV exposition time were also analyzed. The CN characterization showed that formononetin acted as a functionalization agent. The functionalized CN showed safe characteristics and can be incorporated in photocrosslinkable formulation. The UV exposition time for the formulation photopolymerization was compatible with the cell viability and also occurred in the injury site.
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