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T cell responses in patients with COVID-19

2020; Nature Portfolio; Volume: 20; Issue: 9 Linguagem: Inglês

10.1038/s41577-020-0402-6

1474-1741

Zeyu Chen, E. John Wherry,

Long-Term Effects of COVID-19

The role of T cells in the resolution or exacerbation of COVID-19, as well as their potential to provide long-term protection from reinfection with SARS-CoV-2, remains debated. Nevertheless, recent studies have highlighted various aspects of T cell responses to SARS-CoV-2 infection that are starting to enable some general concepts to emerge. In this Progress article, Zeyu Chen and E. John Wherry summarize early reports of the T cell responses observed in patients with COVID-19, emphasizing how different immune response characteristics in different patients may reflect a spectrum of disease phenotypes.