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Cytosponge-trefoil factor 3 versus usual care to identify Barrett's oesophagus in a primary care setting: a multicentre, pragmatic, randomised controlled trial

2020; Elsevier BV; Volume: 396; Issue: 10247 Linguagem: Inglês

10.1016/s0140-6736(20)31099-0

1474-547X

Rebecca C. Fitzgerald, Massimiliano di Pietro, Maria O’Donovan, Roberta Maroni, Beth Muldrew, Irene Debiram‐Beecham, Marcel Gehrung, Judith Offman, Monika Tripathi, Samuel G. Smith, Benoit Aigret, Fiona M Walter, Greg Rubin, Peter Sasieni, Abhay Bagewadi, Abigail Patrick, Achuth Shenoy, Aisling M. Redmond, Ajay Muddu, Alex Northrop, Alice Groves, Alice Shiner, Amardeep Heer, Amrit Takhar, Amy O. Bowles, Andrea Jarman, Angela Wong, Angie Lucas, Anita Gibbons, Anjan Dhar, Anji Curry, Anna Lalonde, Anna Swinburn, Anne I. Turner, Anne Lydon, Anthony Gunstone, Arlene Lee, Arul Nambi, Arun Ariyarathenam, Ashley Elden, Ashley Wilson, Balaji Donepudi, Barbara Campbell, Basia Uszycka, Ben Bowers, Ben Coghill, Bruno de Quadros, Calvin Cheah, Carla Bratten, Carly Brown, Chantelle Moorbey, Charles Clisby, Charles Gordon, Chris Schramm, Chris D Castle, Chris Newark, Chrissie Norris, Christine A’Court, Claire Graham, Clare Fletcher, Clare Grocott, Colin Rees, Corinne Bakker, Costas Paschalides, Craig Vickery, D Schembri, Danielle Morris, Daryl Hagan, David Cronk, David H. Goddard, David Graham, Dean P. Phillips, Deeksha Prabhu, Deepak Kejariwal, Dhirendra Garg, Diane Lonsdale, Dianne Butterworth, Donna Clements, Drew Bradman, D. W. Blake, Elizabeth L. Mather, Ewan O'Farrell, Florian Markowetz, Fran Adams, Francesca Pesola, Gareth Forbes, Gary Taylor, Glenn Collins, Gordon W. Irvine, Gysbert Fourie, H. Doyle, Heather Barnes, Helen Bowyer, Helen Whiting, Ian Beales, Ian Binnian, I. Bremner, Ian Jennings, Ilona Troiceanu, Ines Modelell, Ingrid Emmerson, Jacobo Ortiz, J Lilley, Jacquelyn Harvey, Jacqui Vicars, Jagjit Takhar, James Larcombe, Jan Bornschein, Jehad Aldegather, Jenny Johnson, Jill Ducker, Jo Skinner, Joanne Dash, Joanne Walsh, Jose Miralles, J P Ridgway, J. INCE, Julie Kennedy, Kat Hampson, Kate Milne, Katherine Ellerby, Katherine Priddis, Kathy Rainsbury, Kelly Powell, Kerry Gunner, Krish Ragunath, Kyle Knox, Laura Baseley, Lauren White, Laurence Lovat, Lee Berney, Lindsay Crockett, Lisa Murray, Lisa Westwood, Lisa Chalkley, Loraine Leggett, Louise Dale, Louise Scovell, Lucy Brooks, Lucy Saunders, Lydia Owen, Maria Dilwershah, Marie Baldry, Marie Corcoran, Marie Roy, Mário Espiga de Macedo, M. Y. Attah, M.A.W. Anson, Matt Rutter, Matthew Wallard, Matthew Gaw, Matthew A. Hunt, Megan Lea-Hagerty, Melchizedek Penacerrada, Michele Leonardo Bianchi, Michelle Baker-Moffatt, Michelle Czajkowski, Michelle Sleeth, N.T. Brewer, Nick Wooding, N.W. Todd, N. Millen, Olga Zolle, Orla Whitehead, Patrick Ojechi, Patrick Moore, Paul Banim, Paula Spellar, Pradeep Bhandari, Prashant Kant, Rachel Nixon, Rebecca A. Russell, Rebekah Roberts, Rene Skule, Richard West, Robin Fox, Ruth Beesley, Ruth Gibbins, R.H. Osborne, Shivakumar Thiagarajan, Sally Bastiman, Samantha Warburton, S Pai, Sarah Leith-Russell, Sarah Utting, Sarah Watson, Sarah Wytrykowski, Satish S. Singh, Shalini Malhotra, Sharon Woods, Shaun Conway, Sherrie Mateer, Shona MacRae, Shruti Singh, S Fourie, Siobhán Campbell, Siobhan Parslow-Williams, Sonica Goel, Stephen Dellar, Stephen Jones, S.A. Knight, Stuart Mackay-Thomas, Stuti Mukherjee, Sue Allen, Suzanne Bakken Henry, Tara N. Evans, Theresa Leighton, Tim Bray, Tom Shackleton, V. Krishna Santosh, Vicki Glover, V. Chandraraj, Will Elson, William M. Briggs, Z.L. Zatarain Barrón, Zohrah Khan,

Gastric Cancer Management and Outcomes

Treatment of dysplastic Barrett's oesophagus prevents progression to adenocarcinoma; however, the optimal diagnostic strategy for Barrett's oesophagus is unclear. The Cytosponge-trefoil factor 3 (TFF3) is a non-endoscopic test for Barrett's oesophagus. The aim of this study was to investigate whether offering this test to patients on medication for gastro-oesophageal reflux would increase the detection of Barrett's oesophagus compared with standard management.