Strategies for PET imaging of the receptor for advanced glycation endproducts (RAGE)
2020; Elsevier BV; Volume: 10; Issue: 5 Linguagem: Inglês
10.1016/j.jpha.2020.07.009
ISSN2214-0883
AutoresLindsey Drake, Allen F. Brooks, Jenelle Stauff, Phillip Sherman, Janna Arteaga, Robert A. Koeppe, Aimee Reed, Timothy J. Montavon, Marc B. Skaddan, Peter J. H. Scott,
Tópico(s)Fatty Acid Research and Health
ResumoThe implication of the receptor for advanced glycation end-products (RAGE) in numerous diseases and neurodegenerative disorders makes it interesting both as a therapeutic target and as an inflammatory biomarker. In the context of investigating RAGE as a biomarker, there is interest in developing radiotracers that will enable quantification of RAGE using positron emission tomography (PET) imaging. We have synthesized potential small molecule radiotracers for both the intracellular ([
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