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AIDS-related Cryptococcus neoformans choroiditis

2020; Elsevier BV; Volume: 22; Linguagem: Inglês

10.1016/j.idcr.2020.e00931

2214-2509

Gregory S. Canfield, Sarah Reingold, Andrea Ho, Ann D. Thor, Paula E. Pecen, Kristen DeSanto, Daniel B. Chastain, Carlos Franco‐Paredes, José Castillo‐Mancilla, Andrés F. Henao‐Martínez,

Cytomegalovirus and herpesvirus research

We describe a case of Cryptococcal choroiditis in a person with advanced HIV/AIDS. A 29-year-old male with AIDS presented with fever, photophobia, and ataxia secondary to cryptococcal and toxoplasma meningoencephalitis. Dilated fundoscopic examination revealed bilateral and multifocal posterior infiltrates consistent with cryptococcal choroiditis. Treatment with parenteral and intravitreal liposomal amphotericin B, oral flucytosine, and oral trimethoprim-sulfamethoxazole led to resolution of his symptoms and improvement in his vision. Our case documents a rare, intraocular opportunistic infection and highlights the importance of ophthalmologic examination in immunocompromised hosts with visual symptoms and invasive fungal infection. We discuss diagnostic and treatment considerations in cryptococcal choroiditis.