Copper‐Catalyzed Remote Direct Thiocyanation of Alkyl C( sp 3 )−H Bonds
2020; Wiley; Volume: 362; Issue: 18 Linguagem: Inglês
10.1002/adsc.202000754
ISSN1615-4169
AutoresQian Wang, Peiyuan Tian, Zhong‐Yan Cao, Hongwei Zhang, Cuiyu Jiang,
Tópico(s)Synthesis and Catalytic Reactions
ResumoAbstract A method for site‐selective intermolecular C( sp 3 )−H thiocyanation of aliphatic sulfonamides is developed using cheap trimethylsilyl isothiocyanate (TMSNCS) as the thiocyanation reagent, catalyzed by simple Cu(I)/phenanthroline complex. The mild, and modular protocol allows remote C( sp 3 )−H thiocyanation in promising yields with a broad substrate scope. magnified image
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