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Compulsivity is linked to reduced adolescent development of goal-directed control and frontostriatal functional connectivity

2020; National Academy of Sciences; Volume: 117; Issue: 41 Linguagem: Inglês

10.1073/pnas.1922273117

1091-6490

Matilde M. Vaghi, Michael Moutoussis, František Váša, Rogier Kievit, Tobias U. Hauser, Petra E. Vértes, Nitzan Shahar, Rafael Romero-García, Manfred G. Kitzbichler, Edward T. Bullmore, Raymond J. Dolan, Edward T. Bullmore, Raymond J. Dolan, Ian Goodyer, Peter Fonagy, Peter B. Jones, Michael Moutoussis, Tobias U. Hauser, Sharon Neufeld, Rafael Romero-García, Michelle St Clair, Petra E. Vértes, Kirstie Whitaker, Becky Inkster, Gita Prabhu, Cinly Ooi, Umar Toseeb, Barry Widmer, Junaid Bhatti, Laura Villis, Ayesha Alrumaithi, Sarah Birt, Aislinn Bowler, Kalia Cleridou, Hina Dadabhoy, Emma Davies, Ashlyn Firkins, Sian Granville, Elizabeth Harding, Alexandra Hopkins, Daniel Isaacs, Janchai King, Danae Kokorikou, Christina Maurice, Cleo McIntosh, Jessica Memarzia, Harriet L. Mills, Ciara O’Donnell, Sara Pantaleone, Jenny Scott, Andrea Reiter, Lucy D. Vanes,

Child and Adolescent Psychosocial and Emotional Development

Significance Goal-directed behavior is impaired in disorders of compulsivity. Here, we characterize the developmental trajectory of model-based control and show a progressive strengthening from adolescence to early adulthood. We found that the presence of compulsivity traits impacts on this trajectory as well as on the degree of remodeling in functional connectivity within frontostriatal circuits. These findings have implications for understanding the interplay between compulsivity, the developmental trajectory of model-based planning, and functional connectivity in frontostriatal circuits.