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Association of plasma YKL-40 with brain amyloid-β levels, memory performance, and sex in subjective memory complainers

2020; Elsevier BV; Volume: 96; Linguagem: Inglês

10.1016/j.neurobiolaging.2020.07.009

1558-1497

Andrea Vergallo, Simone Lista, Pablo Lemercier, Patrizia A. Chiesa, Henrik Zetterberg, Kaj Blennow, Marie‐Claude Potier, Marie‐Odile Habert, Filippo Baldacci, Enrica Cavedo, Filippo Caraci, Bruno Dubois, Harald Hampel, Hovagim Bakardjian, Habib Benali, Hugo Bertin, Joel Bonheur, Laurie Boukadida, Nadia Boukerrou, Enrica Cavedo, Patrizia A. Chiesa, Olivier Colliot, Bruno Dubois, Marion Dubois, Stéphane Epelbaum, Geoffroy Gagliardi, Remy Genthon, Marie-Odile Habert, Harald Hampel, Marion Houot, Aurélie Kas, Foudil Lamari, Marcel Levy, Simone Lista, Christiane Metzinger, Fanny Mochel, Francis Nyasse, Catherine Poisson, Marie‐Claude Potier, Marie Revillon, Antonio Santos, Katia Santos Andrade, Marine Sole, Mohmed Surtee, Michel Thiebaut de Schotten, Andrea Vergallo, Nadjia Younsi, Mohammad Afshar, Lisi Flores Aguilar, Leyla Akman-Anderson, Joaquín Arenas, Jesús Ávila, Claudio Babiloni, Filippo Baldacci, Richard Batrla, Norbert Benda, Keith L. Black, Arun L.W. Bokde, Ubaldo Bonuccelli, Karl Broich, Francesco Cacciola, Filippo Caraci, Giuseppe Caruso, Juan Carlos Martínez‐Castrillo, Enrica Cavedo, Roberto Ceravolo, Patrizia A. Chiesa, Massimo Corbo, Jean‐Christophe Corvol, A. Claudio Cuello, Jeffrey L. Cummings, Herman Depypere, Bruno Dubois, Andrea Duggento, Enzo Emanuele, Valentina Escott‐Price, Howard J. Federoff, Maria Teresa Ferretti, Massimo Fiandaca, Richard A. Frank, Francesco Garaci, Hugo Geerts, Ezio Giacobini, Filippo Sean Giorgi, Edward J. Goetzl, Manuela Graziani, Marion Haberkamp, Marie-Odile Habert, Britta Hänisch, Harald Hampel, Karl Herholz, Félix Hernández, Bruno P. Imbimbo, Dimitrios Kapogiannis, Eric Karran, Steven J. Kiddle, Seung Hyun Kim, Yosef Koronyo, Maya Koronyo‐Hamaoui, Todd Langevin, Stéphane Lehéricy, Pablo Lemercier, Simone Lista, Francisco Llavero, Jean Lorenceau, Alejandro Lucía, Dalila Mango, Mark Mapstone, Christian Néri, Robert Nisticò, Sid E. O’bryant, Giovanni Palermo, George Perry, Craig Ritchie, Símone Rossi, Amira Saidi, Emiliano Santarnecchi, Lon S. Schneider, Olaf Sporns, Nicola Toschi, Pedro L. Valenzuela, Bruno Vellas, Steven R. Verdooner, Andrea Vergallo, Nicolas Villain, Kelly Virecoulon Giudici, Mark Watling, Lindsay A Welikovitch, Janet Woodcock, Erfan Younesi, José L. Zugaza,

Studies on Chitinases and Chitosanases

Neuroinflammation, a key early pathomechanistic alteration of Alzheimer's disease, may represent either a detrimental or a compensatory mechanism or both (according to the disease stage). YKL-40, a glycoprotein highly expressed in differentiated glial cells, is a candidate biomarker for in vivo tracking neuroinflammation in humans. We performed a longitudinal study in a monocentric cohort of cognitively healthy individuals at risk for Alzheimer's disease exploring whether age, sex, and the apolipoprotein E ε4 allele affect plasma YKL-40 concentrations. We investigated whether YKL-40 is associated with brain amyloid-β (Aβ) deposition, neuronal activity, and neurodegeneration as assessed via neuroimaging biomarkers. Finally, we investigated whether YKL-40 may predict cognitive performance. We found an age-associated increase of YKL-40 and observed that men display higher concentrations than women, indicating a potential sexual dimorphism. Moreover, YKL-40 was positively associated with memory performance and negatively associated with brain Aβ deposition (but not with metabolic signal). Consistent with translational studies, our results suggest a potentially protective effect of glia on incipient brain Aβ accumulation and neuronal homeostasis.