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Potentiation of antibiotic activity by chalcone (E)-1-(4′-aminophenyl)-3-(furan-2-yl)-prop-2-en-1-one against gram-positive and gram-negative MDR strains

2020; Elsevier BV; Volume: 148; Linguagem: Inglês

10.1016/j.micpath.2020.104453

1096-1208

Carlos A.N. Ferraz, Saulo Relison Tintino, Alexandre Magno Rodrigues Teixeira, Paulo Nogueira Bandeira, Hélcio Silva dos Santos, Beatriz Gonçalves Cruz, C.E.S. Nogueira, Talysson Felismino Moura, Raimundo Luíz Silva Pereira, D.M. Sena, Thiago Sampaio de Freitas, Janaína Esmeraldo Rocha, Henrique Douglas Melo Coutinho,

Multicomponent Synthesis of Heterocycles

Chalcones are α,β-unsaturated ketones containing the 1,3-diarylprop-2-en-1-one framework. This study aims to evaluate the potentiation of antibacterial activity by the chalcone (E)-1-(4-aminophenyl)-3-(furan-2-yl)-prop-2-en-1-one (C13H11NO2), hereafter named AFPO, against multi-resistant strains of Staphylococcus aureus and Escherichia coli. AFPO was synthesized using the Claisen-Schmidt condensation reaction, and the molecular structure was confirmed by nuclear magnetic resonance (NMR). The antibacterial and potentiating properties of AFPO were evaluated by measuring the minimum inhibitory concentration (MIC) using microdilution plates. The AFPO MIC was 1024 μg/mL for the S. aureus 10 strain, revealing synergy in combination with the following antibiotics: penicillin, norfloxacin, ampicillin/sulbactam, and gentamicin. The AFPO MIC was 256 μg/mL for the E. coli 06 strain, and synergy was observed with norfloxacin, gentamicin, and penicillin. The potentiation of antibacterial activity by AFPO was observed against the strains of S. aureus 10 and E. coli 06.