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Recommendations for vaccination in multiple myeloma: a consensus of the European Myeloma Network

2020; Springer Nature; Volume: 35; Issue: 1 Linguagem: Inglês

10.1038/s41375-020-01016-0

1476-5551

Heinz Ludwig, Mario Boccadoro, Philippe Moreau, Jesús F. San Miguel, Michèle Cavo, Charlotte Pawlyn, Sonja Zweegman, Thierry Façon, Christoph Driessen, Roman Hájek, Melitios A. Dimopoulos, Francesca Gay, Hervé Avet‐Loiseau, Evangelos Terpos, Niklas Zojer, Mohamad Mohty, María‐Victoria Mateos, Hermann Einsele, Michel Delforge, Jo Caers, Katja Weisel, Graham Jackson, Laurent Garderet, Monika Engelhardt, Niels W.C.J. van de Donk, Xavier Leleu, Hartmut Goldschmidt, Meral Beksaç, Inger S. Nijhof, Niels Abildgaard, Sara Bringhen, Pieter Sonneveld,

vaccines and immunoinformatics approaches

Abstract Vaccination is one of the most successful medical interventions that has saved the life of millions of people. Vaccination is particularly important in patients with multiple myeloma, who have an increased risk of infections due to the disease-inherent immune suppression, and because of the immune suppressive effects of therapy. Hence, all appropriate measures should be exploited, to elicit an effective immune response to common pathogens like influenza, pneumococci, varicella zoster virus, and to those bacteria and viruses (haemophilus influenzae, meningococci, and hepatitis) that frequently may pose a significant risk to patients with multiple myeloma. Patients after autologous, and specifically after allogeneic transplantation have severely reduced antibody titers, and therefore require a broader spectrum of vaccinations. Response to vaccination in myeloma often is less vigorous than in the general population, mandating either measurement of the postvaccination antibody titers and/or repeating the vaccination. Here, we compile the existing data on vaccination in multiple myeloma and provide recommendations for clinical practice.