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The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson’s disease

2020; Springer Science+Business Media; Volume: 268; Issue: 2 Linguagem: Inglês

10.1007/s00415-020-10156-3

1432-1459

Marina Picillo, Raffaele Palladino, Roberto Erro, Rossella Alfano, Carlo Colosimo, Roberto Marconi, Angelo Antonini, Paolo Barone, Angelo Antonini, Carlo Colosimo, Roberto Marconi, Francesca Morgante, Dario Benincasa, R. Quatrale, Sara Biguzzi, M. Braga, Maria Gabriella Ceravolo, Marianna Capecci, G. Meco, Natalia Caravona, Raffaele Scala, De Falco Fa, Gianni Pezzoli, D. De Gaspari, E. Bottacchi, Matteo Di Giovanni, Antonino Cannas, Gianluca Floris, Simone Gallerini, L. Grasso, Rosa Maria Gaglio, G Gurgone, Giovanni Volpe, Salvatore Zappulla, Roberto Ceravolo, Lorenzo Kiferle, Silvia Ramat, Sara Meoni, Antonio Pisani, Vincenzo Moschella, Francesca Morgante, Rodolfo Savica, Francesco Pepe, Gian Paolo Ciccarelli, V. Petretta, Rosa M. Giglia, Maria Giovanna Randisi, Francesco Iemolo, Tania P. Avarello, M. Romeno, Gabriella Santangelo, Fabrizio Stocchi, Giovanna Sciortino, V. Sorbello, Alessandra Nicoletti, Dorina Tiple, Giovanni Fabbrini, Anna Rita Bentivoglio, Francesco E. Pontieri, Arianna Guidubaldi, Rosalba Muoio, Toni Valković, Paolo Del Dotto, Chiara Logi, G. Ciacci, Monica Ulivelli, Michele Perini, Silvia Lanfranchi, Simona Griffini, B. Troianiello, Mario Baratti, S Amidei, Domenico Consoli, Mattia Anna Iellamo, Teresa Cuomo, A. Scaglioni, Doriana Medici, M. Manfredi, Giovanni Abbruzzese, G. Di Brigida, G. A. Cocco, V. Agnetti, Giovanni Cossu, Marcello Deriu, M. Abrignani, Chiara Modica, G Albani, Elisa Milan, Paolo Martinelli, Cesa Scaglione, M. Mucchiut, Sergio Zanini, F Pennisi, Paola Soliveri, Alberto Albanese, Pederzoli Massimo, Luigi Bartolomei, L. Capus, Laura Ferigo, Riccardo Marano, Valentina Nastasi, Rita Luciano, Luigi Maiello, P. Simone, Danilo Fogli, Leonardo Lopiano, Marina Pesare, Giampietro Nordera, E. Pilleri, T. Scaravilli, E. Giaccaglini, C Alesi, Alfredo Petrone, Giorgio Trianni,

Gastrointestinal motility and disorders

Abstract Objectives To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson’s disease at early stages. Methods A total of 385 Parkinson’s disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women). Results As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only. Conclusions Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson’s disease may impact disease phenotype.