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Detection of Methamphetamine and Amphetamine in a Single Human Hair by Gas Chromatography/Chemical Ionization Mass Spectrometry

1984; Wiley; Volume: 29; Issue: 2 Linguagem: Inglês

10.1520/jfs11712j

1556-4029

Osamu Suzuki, Hideki Hattori, Mai Asano,

Forensic Toxicology and Drug Analysis

A detailed procedure of an extremely sensitive method for quantitation of methamphetamine and amphetamine in human hair by gas chromatography (GC)/chemical ionization (CI) mass spectrometry (MS) is presented. N-methylbenzylamine was used as an internal standard. The samples, after extraction with an organic solvent, were derivatized with trifluoroacetic anhydride before the GC/MS analysis. Quantitation was made with quasi-molecular ions of the derivatives by selected ion monitoring in the CI mode. The detection limit was about 10 pg in an injected volume. The high sensitivity enabled us to measure both stimulants in a single human hair in actual cases.