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“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability

2020; Multidisciplinary Digital Publishing Institute; Volume: 21; Issue: 17 Linguagem: Inglês

10.3390/ijms21176174

1661-6596

Ana Gomes, Lucinda J. Bessa, Patrícia Correia, Iva Fernandes, Ricardo Ferraz, Paula Gameiro, Cátia Teixeira, Paula Gomes,

Microbial Natural Products and Biosynthesis

A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides.