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Rare new bicyclic cembranoid ethers and a novel trihydroxy prenylated guaiane from the Xisha soft coral Lobophytum sp

2020; Elsevier BV; Volume: 103; Linguagem: Inglês

10.1016/j.bioorg.2020.104223

1090-2120

Song‐Wei Li, Cristina Cuadrado, Xia‐Juan Huan, Li‐Gong Yao, Ze‐Hong Miao, Antonio Hernández Daranas, Yue‐Wei Guo,

Chemical synthesis and alkaloids

Seven new cembrane-type diterpenes, lobophytolins C–I (3–9), and one new prenylated-guiane-type diterpene, lobophytolin J (10), along with six known related ones (1, 2, 11–14), have been isolated from the soft coral Lobophytum sp. collected off the Xisha Island in the South China Sea. Their structures were elucidated by extensive spectroscopic analysis and quantum mechanical (QM)-NMR methods. The absolute configuration of lobophytolin H (8) was determined by the application of the modified Mosher's method and chemical transformation. Lobophytolin D (4) exhibited promising cytotoxicities in in vitro bioassays against HT-29, Capan-1, A549, and SNU-398 human cancer cell lines with IC50 values of 4.52, 6.62, 5.17, and 6.15 μM, respectively.