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Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate

2020; American Society for Microbiology; Volume: 58; Issue: 11 Linguagem: Inglês

10.1128/jcm.02107-20

1098-660X

Amin Addetia, Katharine H. D. Crawford, Adam S. Dingens, Haiying Zhu, Pavitra Roychoudhury, Meei‐Li Huang, Keith R. Jerome, Jesse D. Bloom, Alexander L. Greninger,

Influenza Virus Research Studies

The development of vaccines against SARS-CoV-2 would be greatly facilitated by the identification of immunological correlates of protection in humans. However, to date, studies on protective immunity have been performed only in animal models and correlates of protection have not been established in humans. Here, we describe an outbreak of SARS-CoV-2 on a fishing vessel associated with a high attack rate. Predeparture serological and viral reverse transcription-PCR (RT-PCR) testing along with repeat testing after return to shore was available for 120 of the 122 persons on board over a median follow-up of 32.