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Cyperus esculentus L. (tigernut) mitigates high salt diet‐associated testicular toxicity in Wistar rats by targeting testicular steroidogenesis, oxidative stress and inflammation

2020; Wiley; Volume: 52; Issue: 11 Linguagem: Inglês

10.1111/and.13780

1439-0272

Justina Nwandimma Nwangwa, Augustine Lishilinimye Udefa, Ernest Atelhe Amama, Inah Onete Inah, Hamza Joseph Ibrahim, Stephanie Chinelo Iheduru, Nichole Edikan Okorie, Joy Agede Ogar, Faith Nuhu Madaki, Peace Okon Owai, Elayofa Victory Karawei,

Plant Toxicity and Pharmacological Properties

AndrologiaVolume 52, Issue 11 e13780 ORIGINAL ARTICLE Cyperus esculentus L. (tigernut) mitigates high salt diet-associated testicular toxicity in Wistar rats by targeting testicular steroidogenesis, oxidative stress and inflammation Justina Nwandimma Nwangwa, Justina Nwandimma Nwangwa Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorAugustine Lishilinimye Udefa, Corresponding Author Augustine Lishilinimye Udefa [email protected] [email protected] orcid.org/0000-0003-1923-3560 Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Nigeria Correspondence Augustine Lishilinimye Udefa, Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Nigeria. Emails: [email protected]; [email protected]Search for more papers by this authorErnest Atelhe Amama, Ernest Atelhe Amama Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorInah Onete Inah, Inah Onete Inah Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorHamza Joseph Ibrahim, Hamza Joseph Ibrahim Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorStephanie Chinelo Iheduru, Stephanie Chinelo Iheduru Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorNichole Edikan Okorie, Nichole Edikan Okorie Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorJoy Agede Ogar, Joy Agede Ogar Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorFaith Nuhu Madaki, Faith Nuhu Madaki Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorPeace Okon Owai, Peace Okon Owai Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorElayofa Victory Karawei, Elayofa Victory Karawei Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this author Justina Nwandimma Nwangwa, Justina Nwandimma Nwangwa Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorAugustine Lishilinimye Udefa, Corresponding Author Augustine Lishilinimye Udefa [email protected] [email protected] orcid.org/0000-0003-1923-3560 Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Nigeria Correspondence Augustine Lishilinimye Udefa, Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Nigeria. Emails: [email protected]; [email protected]Search for more papers by this authorErnest Atelhe Amama, Ernest Atelhe Amama Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorInah Onete Inah, Inah Onete Inah Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorHamza Joseph Ibrahim, Hamza Joseph Ibrahim Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorStephanie Chinelo Iheduru, Stephanie Chinelo Iheduru Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorNichole Edikan Okorie, Nichole Edikan Okorie Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorJoy Agede Ogar, Joy Agede Ogar Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorFaith Nuhu Madaki, Faith Nuhu Madaki Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorPeace Okon Owai, Peace Okon Owai Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this authorElayofa Victory Karawei, Elayofa Victory Karawei Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, NigeriaSearch for more papers by this author First published: 20 August 2020 https://doi.org/10.1111/and.13780Citations: 2Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract High salt diet (HSD) impairs testicular function via oxidative stress. Cyperus esculentus contains antioxidants and improves testicular function. We investigated the protective effect of hydro-ethanolic extract of Cyperus esculentus on testicular function in HSD-fed Wistar rats. Twenty-five male Wistar rats (125–135 g) 8–9 weeks old were divided into five groups (n = 5): control, HSD-fed (8 % NaCl in feed), extract-treated (500 mg kg−1 day−1), HSD-fed +500 mg kg−1 day−1 of extract and HSD-fed +1,000 mg kg−1 day−1 of extract groups. Treatment lasted for 6 weeks. HSD decreased (p < .05) sperm parameters and serum reproductive hormones levels, while Cyperus esculentus extract improved (p < .05) sperm parameters, and serum testosterone and follicle-stimulating hormone levels in HSD-fed rats. The extract upregulated intra-testicular testosterone level and activities of 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-HSD, downregulated malondialdehyde and nitric oxide levels, and exhibited a dose-dependent decrease in pro-inflammatory cytokines, upregulation of activities of enzymatic antioxidants and increase in total antioxidant capacity in testes of HSD-fed rats. The extract at both doses improved Johnsen's score, Leydig and Sertoli cell counts and seminiferous tubular diameter in HSD-fed rats. Cyperus esculentus exhibited a dose-dependent mitigation of HSD-associated testicular dysfunction by targeting testicular steroidogenesis, oxidative stress and inflammation. CONFLICT OF INTEREST The authors have no conflict of interest to disclose. Citing Literature Volume52, Issue11December 2020e13780 RelatedInformation