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Not just antibodies: B cells and T cells mediate immunity to COVID-19

2020; Nature Portfolio; Volume: 20; Issue: 10 Linguagem: Inglês

10.1038/s41577-020-00436-4

1474-1741

Rebecca Jane Cox, Karl A. Brokstad,

Long-Term Effects of COVID-19

Recent reports that antibodies to SARS-CoV-2 are not maintained in the serum following recovery from the virus have caused alarm. However, the absence of specific antibodies in the serum does not necessarily mean an absence of immune memory. Here, we discuss our current understanding of the relative contribution of B cells and T cells to immunity to SARS-CoV-2 and the implications for the development of effective treatments and vaccines for COVID-19. Here, Cox and Brokstad briefly discuss T cell- and B cell-mediated immunity to SARS-CoV-2, stressing that a lack of serum antibodies does not necessarily equate with a lack of immunity to the virus.