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Anti-inflammatory Activity of Etlingera elatior (Jack) R.M. Smith Flower on Gastric Ulceration-induced Wistar Rats

2020; Asian Network for Scientific Information; Volume: 23; Issue: 9 Linguagem: Inglês

10.3923/pjbs.2020.1193.1200

1812-5735

Tanti Juwita, Wenni H.P. Pakpa, Irma Maya Puspita, Nyi Mekar Sapt, Jutti Levita,

Phytochemical compounds biological activities

Background and Objective: Etlingera elatior (Jack) R.M. Smith rhizome, which has been traditionally used to reduce stomach discomfort, was reported to possess anti-inflammatory activity, however, there is a lack of such a study on the flower.Materials and Methods: To investigate the anti-inflammatory activity of the E. elatior flower extract on gastric ulceration-induced Wistar rats.The Wistar rats were divided into 6 groups.Group 1 was the normal control, group 2 was the negative control (Arabic gum suspension 2%), group 3 was the positive control (quercetin), group 4-6 were treated with E. elatior flower extract dose of 500, 1000 and 2000 mg kgG 1 of b.wt., respectively.The rats were conditioned to gastric ulceration.The stomach weight, microscopic and macroscopic evaluation of gastric mucosal damage was examined.Subsequently, the nuclear factor-kappaB-p65 (NF-kappaB-p65) expression in the fundus was Westernblotted by employing $-actin and GAPDH as the loading controls.Results: Etlingera elatior flower extract dose of 1000 mg kgG 1 b.wt., reduces the ulceration index and the infiltration of inflammatory cells.Western blot analysis showed inhibition of NF-kappaB-p65 expression by E. elatior flower extract dose of 1000 mg kgG 1 of b.wt.Conclusion: Etlingera elatior flower might possess anti-inflammatory activity by downregulating the expression of NF-kappaB-p65 in the fundus of gastric ulceration-induced Wistar rats.