Produção Nacional
Revisado por pares
Association of HIV infection with clinical and laboratory characteristics of sickle cell disease
2020; BioMed Central; Volume: 20; Issue: 1 Linguagem: Inglês
10.1186/s12879-020-05366-z
ISSN1471-2334
AutoresAndré Rolim Belisário, Paula Fraiman Blatyta, Diana Vivanco, Cláudia Di Lorenzo Oliveira, Anna Bárbara de Freitas Carneiro-Proietti, Éster Cerdeira Sabino, Cesar de Almeida‐Neto, Paula Loureiro, Cláudia Máximo, Sheila de Oliveira Garcia Mateos, Miriam V. Flor‐Park, Daniela de Oliveira Werneck Rodrigues, Rosimere Afonso Mota, Thelma T. Gonçalez, Thomas J. Hoffmann, Shannon Kelly, Brian Custer, Éster Cerdeira Sabino, Cecília Salete Alencar, Alfredo Mendrone, Cesar de Almeida‐Neto, Ligia Capuani, Miriam V. Flor‐Park, Paula Fraiman Blatyta, Anna Bárbara de Freitas Carneiro-Proietti, Carolina Miranda Teixeira, Tassila Salomon, Franciane Mendes de Oliveira, Valquíria Reis, Rosemere Afonso Mota, José Wilson Sales, Daniela de Oliveira Werneck, Paula Loureiro, Aderson da Silva Araújo, Maria do Carmo Valgueir, Clarisse Lopes de Castro Lobo, Cláudia Máximo, João Eduardo Ferreira, Márcio K. Oikawa, Pedro Losco Takecian, Mina Cintho Ozahata, Rodrigo Muller de Carvalho, Brian Custer, Michael P. Busch, Shannon Kelly, Thelma T. Gonçalez, Donald Brambilla, Liliana Preiss, Christopher McClure,
Tópico(s)Parvovirus B19 Infection Studies
ResumoAbstract Background Sickle cell disease (SCD) is a multisystem disorder characterized by a wide spectrum of clinical manifestations and severity. Studies investigating potential effects of co-morbid human immunodeficiency virus (HIV) and SCD have produced conflicting results, and additional investigations are needed to elucidate whether the interaction between the two disease states might impact both HIV and SCD clinical outcomes. The association of HIV infection with clinical and laboratory characteristics of patients with SCD was assessed. Methods This nested case-control study included individuals with SCD with HIV treated at six Brazilian SCD centers. Clinical and laboratory data were abstracted from medical records. HIV positive participants were compared to age, gender, center, and SCD genotype matched HIV negative participants (ratio 1:4). Individual clinical outcomes as well as a composite outcome of any SCD complication and a composite outcome of any HIV-related complication were compared between the two groups. Results Fifteen HIV positive participants were included, 12 (80%) alive and 3 (20%) deceased. Most of the HIV positive patients had HbSS (60%; n = 9), 53% ( n = 8) were female, and mean age was 30 ± 13 years. The frequency of individual SCD complications of acute chest syndrome/pneumonia, sepsis/bacteremia, pyelonephritis, ischemic stroke, hemorrhagic stroke, abnormal transcranial Doppler (TCD), and pulmonary hypertension was higher in HIV positive participants when compared to HIV negative, although analyzed individually none were statistically significant. HIV positive participants had significantly higher risk of any SCD complication and of a composite HIV-related complication compared to the HIV negative group (HR = 4.6; 95%CI 1.1–19.6; P = 0.04 and HR = 7.7; 95%CI 1.5–40.2; P = 0.02, respectively). There was a non-significant trend towards higher risk of any infections in participants with HIV positive (HR = 3.5; 95%CI 0.92–13.4; P = 0.07). Laboratory parameters levels were not significantly different in individuals with and without HIV. Conclusions In summary, our study in SCD patients shows that those with HIV have an increased risk of any SCD complication and HIV-related complications, as well as a suggestive but not significantly increased risk of infections.
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