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The H-NS Regulator Plays a Role in the Stress Induced by Carbapenemase Expression in Acinetobacter baumannii

2020; American Society for Microbiology; Volume: 5; Issue: 4 Linguagem: Inglês

10.1128/msphere.00793-20

2379-5042

Fanny Huang, Noelle Fitchett, Chelsea Razo-Gutierrez, Casin Le, Jasmine Martinez, Grace Ra, Carolina López, Lisandro J. González, Rodrigo Sieira, Alejandro J. Vila, Robert A. Bonomo, María Soledad Ramirez,

Escherichia coli research studies

Carbapenem-resistant A. baumannii (CRAB) is recognized as one of the most threatening Gram-negative bacilli. H-NS is known to play a role in controlling the transcription of a variety of different genes, including those associated with the stress response, persistence, and virulence. In the present work, we uncovered a link between the role of H-NS in the A. baumannii stress response and its relationship with the envelope stress response and resistance to DNA-damaging agents. Overall, we posit a new role of H-NS, showing that H-NS serves to endure envelope stress and could also be a mechanism that alleviates the stress induced by MBL expression in A. baumannii . This could be an evolutionary advantage to further resist the action of carbapenems.