Portal de Periódicos da CAPES

The effect of gender on disease activity and clinical characteristics in patients with axial psoriatic arthritis

2020; Oxford University Press; Volume: 31; Issue: 4 Linguagem: Inglês

10.1080/14397595.2020.1812870

1439-7609

Kemal Nas, Erkan Kılıç, İbrahim Tekeoğlu, Yaşar Keskin, Remzi Çevik, Betül Sargın, Sevtap Acer Kasman, Hakan Alkan, Nilay Şahin, Gizem Cengiz, Nihan Cüzdan, İlknur Albayrak Gezer, Dilek Keskin, Cevriye Mülkoğlu, Hatice Reşorlu, Şebnem Ataman, Ajda Bal, Merve Baykul, Mehmet Tuncay Duruöz, Okan Küçükakkaş, Ozan Volkan Yurdakul, Meltem Alkan Melikoğlu, Fikriye Figen Ayhan, Hatice Bodur, Mustafa Çalış, Erhan Çapkın, Gül Devrimsel, Kevser Gök, Sami Hizmetli, Ayhan Kamanlı, Hilal Kocabaş, Öznur Kutluk, Nesrin Şen, Ömer Faruk Şendur, Murat Toprak, Sena Tolu, Tiraje Tuncer,

Autoimmune and Inflammatory Disorders Research

In this study, we aimed to evaluate the effect of gender on clinical findings, disease activity, functional status and quality of life in patients with axial involvement in Turkey.Patients with PsA who met the CASPAR classification criteria were enrolled consequently in this cohort. Turkish League Against Rheumatism (TLAR)-Network was formed with the participation of 25 centres. The demographic variables, fatigue, diagnostic delay, the beginning of peripheral arthritis, enthesitis, dactylitis and spine involvement, inflammatory low back pain, BASFI, HAQ, HAQ-s, visual analogue scale-pain (VAS-pain), anxiety, depression and disease activity parameters (ESR, DAS28, BASDAI) were recorded. Axial involvement was assessed according to clinical and radiological data according to modified New York (MNYC) or Assessment of SpondyloArthritis international Society (ASAS) criteria.A total of 1018 patients with PsA were included in this study. Of the 373 patients with axial involvement, 150 were male (40.2%) and 223 (59.8%) were female. Spondylitis was detected in 14,7% of men and 21,9% of women in all patients. Pain score (VAS) (p < .002), fatigue (p < .001), ESR (p < .001), DAS28 (p < .001), BASDAI score (p < .001), PsAQoL (p < .001), HAQ score (p < ,01), HAQ-S score (p < .001), anxiety (p < .001), depression (p < .024), FACIT (p < .001) and FiRST (p < .001) scores were statistically significantly worse in women than males with axial PsA. However, quality of life was better (p < .001) and PASI score (p < .005) were statistically worse in male patients than in female patients with axial involvement.This study has shown that the burden of disease in axial PsA has significant difference between genders. Disease activity, physical disability, functional limitation, depression and anxiety scores were higher in female patients, while quality of life were better and PASI score were higher in male patients. Therefore, we suggest that new strategies should be developed for more effective treatment of axial PsA in female patients.