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Clinical Characteristics and Outcomes of 821 Older Patients With SARS-Cov-2 Infection Admitted to Acute Care Geriatric Wards

2020; Oxford University Press; Volume: 76; Issue: 3 Linguagem: Inglês

10.1093/gerona/glaa210

1758-535X

Lorène Zerah, Édouard Baudouin, Marion Pépin, Morgane Mary, Sébastien Krypciak, Céline Bianco, Swasti Roux, A Gross, Charlotte Toméo, Nadège Lemarié, Antoine Dureau, Sophie Bastiani, Flora Ketz, Clémence Boully, C. de Villelongue, Mouna Romdhani, Marie-Astrid Desoutter, Emmanuelle Duron, Jean‐Philippe David, Caroline Thomas, Éléna Paillaud, Pauline de Malglaive, Éric Bouvard, Mathilde Lacrampe, E. Mercadier, Alexandra Monti, Olivier Hanon, Virginie Fossey-Diaz, Lauriane Bourdonnec, Bruno Riou, Hélène Vallet, Jacques Boddaert,

Intensive Care Unit Cognitive Disorders

Abstract Background There is limited information describing the characteristics and outcomes of hospitalized older patients with confirmed coronavirus disease 2019 (COVID-19). Method We conducted a multicentric retrospective cohort study in 13 acute COVID-19 geriatric wards, from March 13 to April 15, 2020, in Paris area. All consecutive patients aged 70 years and older, with confirmed COVID-19, were enrolled. Results Of the 821 patients included in the study, the mean (SD) age was 86 (7) years; 58% were female; 85% had ≥2 comorbidities; 29% lived in an institution; and the median [interquartile range] Activities of Daily Living scale (ADL) score was 4 [2–6]. The most common symptoms at COVID-19 onset were asthenia (63%), fever (55%), dyspnea (45%), dry cough (45%), and delirium (25%). The in-hospital mortality was 31% (95% confidence interval [CI] 27–33). On multivariate analysis, at COVID-19 onset, the probability of in-hospital mortality was increased with male gender (odds ratio [OR] 1.85; 95% CI 1.30–2.63), ADL score <4 (OR 1.84; 95% CI 1.25–2.70), asthenia (OR 1.59; 95% CI 1.08–2.32), quick Sequential Organ Failure Assessment score ≥2 (OR 2.63; 95% CI 1.64–4.22), and specific COVID-19 anomalies on chest computerized tomography (OR 2.60; 95% CI 1.07–6.46). Conclusions This study provides new information about older patients with COVID-19 who are hospitalized. A quick bedside evaluation at admission of sex, functional status, systolic arterial pressure, consciousness, respiratory rate, and asthenia can identify older patients at risk of unfavorable outcomes.