
Genotoxicity and mutagenicity research in Quilombola communities
2020; Nature Portfolio; Volume: 10; Issue: 1 Linguagem: Inglês
10.1038/s41598-020-71195-4
ISSN2045-2322
AutoresAroldo Vieira de Moraes Filho, João Antônio Xavier Manso, Wanderléia Eleutério Martins, Núbia Aguiar Marinho, Mônica de Oliveira Santos, José Perim Neto, Sabrina Sara Moreira Duarte, Aparecido Divino da Cruz, Cláudio Carlos da Silva, Mônica Santiago Barbosa, Débora de Jesus Pires, Lílian Carla Carneiro,
Tópico(s)Environmental Toxicology and Ecotoxicology
ResumoThe Quilombola communities are mostly isolated and deprived of sources of treated water, garbage collection and sewage, consuming fresh water from wells, streams, lakes, among others. This lack of basic infrastructure can be a relevant factor in exposing residents to substances and factors that are harmful to the integrity of their genetic material that can lead to carcinogenesis. Based on this, the objective of this study was to evaluate the genomic and mutagenic/cytotoxic damage in the adult population of two Quilombola communities (one urban and another rural region), in the state of Goiás, Brazil. For this purpose, the leukocyte of peripheral blood Comet Assay in 68 individuals and Micronucleus Test from exfoliated buccal cells of oral mucosa in 21 volunteers were performed. The results evidenced genomic damage, especially for the community of Aparecida de Goiânia city, which detected significant values (p < 0.05), for the length of the comet's tail and for of the Olive Tail Moment. In the micronucleus test, significant differences were only detected (p < 0.05), when it came to the distribution of nuclear changes among the groups. Therefore, it is essential to perform constant population biomonitoring studies to help guarantee health and, consequently, the quality of life.
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