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Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol

2020; Elsevier BV; Volume: 75; Linguagem: Inglês

10.6061/clinics/2020/e2294

1980-5322

Juliana Carvalho Ferreira, Chung-Chou H. Chang, Bruno Adler Maccagnan Pinheiro Besen, Luiz M.S. Malbuisson, Leandro Utino Taniguchi, Pedro Vitale Mendes, Eduardo Leite Vieira Costa, Marcelo Park, Renato Daltro-Oliveira, Roberta Muriel Longo Roepke, João Manoel Silva, Maria José Carvalho Carmona, Carlos Roberto Ribeiro de Carvalho, Adriana Sayuri Hirota, Alberto Kendy Kanasiro, Alessandra Crescenzi, Amanda Coelho Fernandes, Anna Miethke-Morais, Arthur Petrillo Bellintani, Artur Ribeiro Canasiro, Bárbara Vieira Carneiro, Beatriz Keiko Zanbon, Bernardo Pinheiro de Senna Nogueira Batista, Bianca Ruiz Nicolao, Bruno Adler Maccagnan Pinheiro Besen, Bruno Biselli, Bruno Rocha de Macedo, Caio Machado Gomes De Toledo, Carlos Eduardo Pompílio, Carlos Roberto Ribeiro de Carvalho, Caroline Gomes Mól, Cassio Stipanich, Cauê Gasparotto Bueno, Cibele Larrosa Garzillo, Clarice Tanaka, Daniel Neves Forte, Daniel Joelsons, Daniele Robira, Eduardo Leite Vieira Costa, Élson Mendes da Silva, Fabiane Aliotti Regalio, Gabriela Cardoso Segura, Gustavo Brasil Marcelino, Giulia Sefrin Louro, Chung-Chou H. Chang, Isabela Argollo Ferreira, Jeison de Oliveira Gois, João Manoel Silva, José Otto Reusing, Julia Fray Ribeiro, Juliana Carvalho Ferreira, Karine Vusberg Galleti, Katia Regina da Silva, Larissa Padrão Isensee, Larissa dos Santos Oliveira, Leandro Utino Taniguchi, Leila Suemi Harima Letaif, Lígia Trombetta Lima, Lucas Yongsoo Park, Lucas Chaves, Luciana Cassimiro Nobrega, Luciana Haddad, Ludhmila Abrahão Hajjar, Luíz Marcelo Sá Malbouisson, Manuela Cristina Adsuara Pandolfi, Marcelo Park, Maria José Carvalho Carmona, Maria Castilho Prandini H De Andrade, Mariana Moreira Santos, Matheus Pereira Bateloche, Mayra Akimi Suiama, Mayron F. Oliveira, Mayson Laércio de Araújo Sousa, Michelle Louvaes, Natassja Huemer, Pedro Vitale Mendes, Paulo Ricardo Gessolo Lins, Pedro Gaspar Dos Santos, Pedro Ferreira Paiva Moreira, Renata Mello Guazzelli, Renato Batista Dos Reis, Renato Daltro De Oliveira, Roberta Muriel Longo Roepke, Rodolpho Augusto de Moura Pedro, Rodrigo Kondo, Samia Zahi Rached, Sergio Roberto Silveira Da Fonseca, Thais Sousa Borges, Thalissa Ferreira, Vilson Cobello, Vivian Vieira Tenório Sales, Willaby Serafim Cassa Ferreira,

Long-Term Effects of COVID-19

We designed a cohort study to describe characteristics and outcomes of patients with coronavirus disease (COVID-19) admitted to the intensive care unit (ICU) in the largest public hospital in Sao Paulo, Brazil, as Latin America becomes the epicenter of the pandemic.This is the protocol for a study being conducted at an academic hospital in Brazil with 300 adult ICU beds dedicated to COVID-19 patients. We will include adult patients admitted to the ICU with suspected or confirmed COVID-19 during the study period. The main outcome is ICU survival at 28 days. Data will be collected prospectively and retrospectively by trained investigators from the hospital's electronic medical records, using an electronic data capture tool. We will collect data on demographics, comorbidities, severity of disease, and laboratorial test results at admission. Information on the need for advanced life support and ventilator parameters will be collected during ICU stay. Patients will be followed up for 28 days in the ICU and 60 days in the hospital. We will plot Kaplan-Meier curves to estimate ICU and hospital survival and perform survival analysis using the Cox proportional hazards model to identify the main risk factors for mortality. ClinicalTrials.gov: NCT04378582.We expect to include a large sample of patients with COVID-19 admitted to the ICU and to be able to provide data on admission characteristics, use of advanced life support, ICU survival at 28 days, and hospital survival at 60 days.This study will provide epidemiological data about critically ill patients with COVID-19 in Brazil, which could inform health policy and resource allocation in low- and middle-income countries.