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rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis

2020; Elsevier BV; Volume: 74; Issue: 1 Linguagem: Inglês

10.1016/j.jhep.2020.08.027

1600-0641

K. Teo, Kushala Abeysekera, Leon A. Adams, Elmar Aigner, Quentin M. Anstee, Jesús M. Bañales, Rajarshi Banerjee, P. Basu, Thomas Berg, Pallav Bhatnagar, Stephan Buch, Ali Canbay, Sonia Caprio, A Chatterjee, Yii‐Der Ida Chen, Abhijit Chowdhury, Ann K. Daly, Christian Datz, Dana de Gracia Hahn, Johanna K. DiStefano, Jiawen Dong, Amédine Duret, Connor A. Emdin, Madison Fairey, Glenn S. Gerhard, Xiuqing Guo, Jochen Hampe, Matthew Hickman, Lena Heintz, Christian Hudert, Harriet Hunter, Matt Kelly, Julia Kozlitina, Marcin Krawczyk, Frank Lammert, Claudia Langenberg, Joel E. Lavine, Lin Li, Hong Kai Lim, Rohit Loomba, Panu K. Luukkonen, Phillip E. Melton, Trevor A. Mori, Nicholette D. Palmer, Constantinos A. Parisinos, Sreekumar Pillai, Faiza Qayyum, Matthias Reichert, Stefano Romeo, Jerome I. Rotter, Yu Ri Im, Nicola Santoro, Clemens Schafmayer, Elizabeth K. Speliotes, Stefan Stender, Felix Stickel, Christopher D. Still, Pavel Strnad, Kent D. Taylor, Anne Tybjærg‐Hansen, Giuseppina Rosaria Umano, Mrudula Utukuri, Luca Valenti, Lynne E. Wagenknecht, Nicholas J. Wareham, Richard M. Watanabe, Julia Wattacheril, Hanieh Yaghootkar, Hannele Yki‐Järvinen, Kendra A. Young, Jake P. Mann, Anita Vreugdenhil, Anna Alisi, Piotr Socha, Wojciech Jańczyk, Ulrich Baumann, Sanjay Rajwal, Indra van Mourik, Florence Lacaille, M. Dabbas, Déirdre Kelly, Valério Nobili, Guðný Eiríksdóttir, Melissa E. Garcia, Vilmundur Guðnason, Tamara B. Harris, Lauren J. Kim, Lenore J. Launer, Michael A. Nalls, Albert V. Smith, Jeanne M. Clark, Rubén Hernáez, Wei-Tang Kao, Braxton D. Mitchell, Alan R. Shuldiner, Laura M. Yerges‐Armstrong, Ingrid B. Borecki, J. Jeffrey Carr, Mary F. Feitosa, Jun Wu, Johannah L. Butler, Caroline S. Fox, Joel N. Hirschhorn, Udo Hoffmann, Shih‐Jen Hwang, Joseph M. Massaro, Christopher J. O’Donnell, Cameron D. Palmer, Dushyant V. Sahani, Elizabeth K. Speliotes,

Diet, Metabolism, and Disease

A common genetic variant near MBOAT7 (rs641738C>T) has been previously associated with hepatic fat and advanced histology in NAFLD; however, these findings have not been consistently replicated in the literature. We aimed to establish whether rs641738C>T is a risk factor across the spectrum of NAFLD and to characterise its role in the regulation of related metabolic phenotypes through a meta-analysis.