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Case Report: Adrenal Pathology Findings in Severe COVID-19: An Autopsy Study

2020; American Society of Tropical Medicine and Hygiene; Volume: 103; Issue: 4 Linguagem: Inglês

10.4269/ajtmh.20-0787

1476-1645

Monique Freire Santana, Mayla Gabriela Silva Borba, Djane Clarys Baía-da-Silva, Fernando Val, Márcia Almeida Araújo Alexandre, José Diego Brito-Sousa, Gisely Cardoso de Melo, Marcos Vinícius Oliveira Queiroga, Maria Eduarda Leão de Farias, Cecília Cunha Camilo, Felipe Gomes Naveca, Mariana Simão Xavier, Wuelton Marcelo Monteiro, Guilherme Augusto Pivoto João, Ludhmila Abrahão Hajjar, Jaume Ordï, Marcus Lacerda, Luíz Carlos Lima Ferreira,

COVID-19 Clinical Research Studies

Although high mortality has been reported in many COVID-19 studies, very limited postmortem information from complete autopsies is available. We report the findings in the adrenal glands in 28 autopsies with confirmed SARS-CoV-2 infection. Microscopic lesions were identified in the adrenal glands in 12/28 patients (46%). Seven cases showed necrosis, generally ischemic; four showed cortical lipid degeneration; two showed hemorrhage; and one unspecific focal adrenalitis. Vascular thrombosis in one patient and focal inflammation in association with other findings in three patients were observed. No case presented adrenal insufficiency. In conclusion, adrenal lesions are frequent in patients with severe COVID-19. The lesions are mild but could contribute to the lethal outcome.