Portal de Periódicos da CAPES

Genome-wide association study identifies 48 common genetic variants associated with handedness

2020; Nature Portfolio; Volume: 5; Issue: 1 Linguagem: Inglês

10.1038/s41562-020-00956-y

2397-3374

Gabriel Cuéllar-Partida, Joyce Y. Tung, Nicholas Eriksson, Eva Albrecht, Fazil Alıev, Ole A. Andreassen, Inês Barroso, J. Beckmann, Marco P. Boks, Dorret I. Boomsma, Heather A. Boyd, Monique M.B. Breteler, Harry Campbell, Daniel I. Chasman, Lynn Cherkas, Gail Davies, Eco J. C. de Geus, Ian J. Deary, Panos Deloukas, Danielle M. Dick, David L. Duffy, Johan G. Eriksson, Tõnu Esko, Bjarke Feenstra, Frank Geller, Christian Gieger, Ina Giegling, Scott D. Gordon, Jiali Han, Thomas Hansen, Annette M. Hartmann, Caroline Hayward, Kauko Heikkilä, Andrew A. Hicks, Joel N. Hirschhorn, Jouke‐Jan Hottenga, Jennifer E. Huffman, Liang‐Dar Hwang, M. Arfan Ikram, Jaakko Kaprio, John P. Kemp, Kay‐Tee Khaw, Norman Klopp, Bettina Konte, Zoltán Kutalik, Jari Lahti, Xin Li, Ruth J. F. Loos, Michelle Luciano, Sigurður H. Magnússon, Massimo Mangino, Pedro Marques‐Vidal, Nicholas G. Martin, Wendy L. McArdle, Mark I. McCarthy, Carolina Medina‐Gómez, Mads Melbye, Scott A. Melville, Andres Metspalu, Lili Milani, Vincent Mooser, Mari Nelis, Dale R. Nyholt, Kevin S. O’Connell, Roel A. Ophoff, Cameron D. Palmer, Aarno Palotie, Teemu Palviainen, Guillaume Paré, Lavinia Paternoster, Leena Peltonen, Brenda W.J.H. Penninx, Ozren Polašek, Peter P. Pramstaller, Inga Prokopenko, Katri Räikkönen, Samuli Ripatti, Fernando Rivadeneira, Igor Rudan, Dan Rujescu, Johannes H. Smit, George Davey Smith, Jordan W. Smoller, Nicole Soranzo, Tim D. Spector, Beaté St Pourcain, John M. Starr, Hreinn Stefánsson, Stacy Steinberg, Maris Teder‐Laving, Guðmar Þorleifsson, Kāri Stefánsson, Nicholas J. Timpson, André G. Uitterlinden, Cornelia M. van Duijn, Frank J.A. van Rooij, Jaqueline M. Vink, Péter Vollenweider, Eero Vuoksimaa, Gérard Waeber, Nicholas J. Wareham, Nicole M. Warrington, Dawn Waterworth, Thomas Werge, H.‐Erich Wichmann, Elisabeth Widén, Gonneke Willemsen, Alan F. Wright, Margaret J. Wright, Mousheng Xu, Jing Hua Zhao, Peter Kraft, David A. Hinds, Cecilia M. Lindgren, Reedik Mägi, Benjamin M. Neale, David M. Evans, Sarah E. Medland,

Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10−8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders. A genome-wide association study of 1.7 million individuals identified 41 genetic variants associated with left-handedness and 7 associated with ambidexterity. The genetic correlation between the traits was low, thereby implying different aetiologies.