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Gelatin‐Coated Dual Cross‐Linked Sodium Alginate/Magnetite Nanoparticle Microbeads for Controlled Release of Doxorubicin

2020; Wiley; Volume: 5; Issue: 33 Linguagem: Inglês

10.1002/slct.202002604

2365-6549

Sreekanth Reddy Obireddy, C. Madhavi, Chowdoji Rao Kashayi, Krishna Rao Kummari Subba Venkata, Subha Marata Chinna Subbarao,

Advanced Drug Delivery Systems

Abstract The aim of the present work is fabrication of gelatin (GL) coated dual cross‐linked sodium alginate (SA)/magnetite nanoparticles (MNPs) microbeads as potential drug vehicle for extended release of doxorubicin (DOX). The microbeads were prepared using in situ ion‐exchange followed by simple ionotropic gelation technique. The developed beads were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X‐ray diffraction (XRD) and scanning electron microscopy (SEM). Swelling studies and in vitro release studies were investigated in pH 1.2, 5.0 and 7.4 at 37 °C. Results suggested that both the swelling and in vitro release studies were influenced by the pH of test media, which might be suitable for intestinal drug delivery. The release mechanism was analyzed by fitting the release data into Korsmeyer‐Peppas equation. The results suggest that the fabricated DOX loaded compounds are good drug delivery carriers for drug delivery applications.