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Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

2020; Nature Portfolio; Volume: 21; Issue: 11 Linguagem: Inglês

10.1038/s41590-020-0782-6

1529-2916

Yanchun Peng, Alexander J. Mentzer, Guihai Liu, Xuan Yao, Zixi Yin, Danning Dong, Wanwisa Dejnirattisai, Timothy Rostron, Piyada Supasa, Chang Liu, César López‐Camacho, Jose Slon-Campos, Yuguang Zhao, David I. Stuart, Guido C. Paesen, J.M. Grimes, Alfred A. Antson, Oliver W. Bayfield, Dorothy E. D. P. Hawkins, De‐Sheng Ker, Beibei Wang, Lance Turtle, Krishanthi Subramaniam, Paul Thomson, Ping Zhang, Christina Dold, Jeremy Ratcliff, Peter Simmonds, Thushan I. de Silva, Paul Sopp, Dannielle Wellington, Ushani Rajapaksa, Yi‐Ling Chen, Mariolina Salio, Giorgio Napolitani, Wayne Paes, Persephone Borrow, Benedikt M. Kessler, Jeremy Fry, Nikolai F. Schwabe, Malcolm G. Semple, J. Kenneth Baillie, Shona C. Moore, Peter Openshaw, M. Azim Ansari, Susanna Dunachie, Eleanor Barnes, John Frater, Georgina Kerr, Philip Goulder, Teresa Lockett, Robert H. Levin, Yonghong Zhang, Ru‐yang Jing, Ling‐Pei Ho, Eleanor Barnes, Danning Dong, Tao Dong, Susanna Dunachie, John Frater, Philip Goulder, Georgina Kerr, Paul Klenerman, Guihai Liu, Andrew J. McMichael, Giorgio Napolitani, Graham S. Ogg, Yanchun Peng, Mariolina Salio, Xuan Yao, Zixi Yin, J. Kenneth Baillie, Paul Klenerman, Alexander J. Mentzer, Shona C. Moore, Peter Openshaw, Malcolm G. Semple, David I. Stuart, Lance Turtle, Richard J. Cornall, Christopher P. Conlon, Paul Klenerman, Gavin Screaton, Juthathip Mongkolsapaya, Andrew J. McMichael, Julian C. Knight, Graham S. Ogg, Tao Dong,

Long-Term Effects of COVID-19

The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 with severe disease) and 16 unexposed donors, using interferon-γ-based assays with peptides spanning SARS-CoV-2 except ORF1. The breadth and magnitude of T cell responses were significantly higher in severe as compared with mild cases. Total and spike-specific T cell responses correlated with spike-specific antibody responses. We identified 41 peptides containing CD4