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LifeTime and improving European healthcare through cell-based interceptive medicine

2020; Nature Portfolio; Volume: 587; Issue: 7834 Linguagem: Inglês

10.1038/s41586-020-2715-9

1476-4687

Nikolaus Rajewsky, Geneviève Almouzni, Stanislaw A. Gorski, Stein Aerts, Ido Amit, Michela G. Bertero, Christoph Bock, Annelien L. Bredenoord, Giacomo Cavalli, Susanna Chiocca, Hans Clevers, Bart De Strooper, Angelika Eggert, Jan Ellenberg, Xosé M. Fernández, Marek Figlerowicz, Susan M. Gasser, Norbert Hübner, Jørgen Kjems, Juergen A. Knoblich, Grietje Krabbe, Peter Lichter, Sten Linnarsson, Jean‐Christophe Marine, John C. Marioni, Marc A. Martí‐Renom, Mihai G. Netea, Dörthe Nickel, Marcelo Nöllmann, Halina R. Novak, Helen Parkinson, Stefano Piccolo, Inês Pinheiro, Ana Pombo, Christian Popp, Wolf Reik, Sergio Román-Román, Philip Rosenstiel, Joachim L. Schultze, Oliver Stegle, Amos Tanay, Giuseppe Testa, Dimitris Thanos, Fabian J. Theis, Maria‐Elena Torres‐Padilla, Alfonso Valencia, Céline Vallot, Alexander van Oudenaarden, Marie Vidal, Thierry Voet, Lavinia Albéri, Stephanie Alexander, Theodore Alexandrov, Ernest Arenas, Claudia Bagni, Robert Balderas, Andrea Bandelli, Burkhard Becher, Matthias Becker, Niko Beerenwinkel, Monsef Benkirame, Marc Beyer, Wendy A. Bickmore, Erik E. A. L. Biessen, Niklas Blomberg, Ingmar Blümcke, Bernd Bodenmiller, Barbara Borroni, Dimitrios T. Boumpas, Thomas Bourgeron, Sarion R. Bowers, Dries Braeken, Cath Brooksbank, Nils Brose, Hilgo Bruining, Jo Bury, Nicolò Caporale, Giorgio Cattoretti, Nadia Chabane, Hervé Chneiweiss, Stuart A. Cook, Paolo Curatolo, Marien I. de Jonge, Bart De Strooper, Bart De Strooper, Peter de Witte, Stefanie Dimmeler, Bogdan Draganski, Anna Drews, Costică Dumbravă, Stefan Engelhardt, Thomas Gasser, Evangelos J. Giamarellos-Bourboulis, Caroline Graff, Dominic Grün, Marta Gut, Oskar Hansson, David C. Henshall, Anna Herland, Peter Heutink, Stéphane Heymans, Holger Heyn, Meritxell Huch, Inge Huitinga, Paulina Jackowiak, Karin Jongsma, Laurent Journot, Jan Philipp Junker, Shauna Katz, Jeanne Kehren, Stefan Kempa, Paulus Kirchhof, Christine Klein, Natalia Koralewska, Jan O. Korbel, Malte Kühnemund, Angus I. Lamond, Elsa Lauwers, Isabelle Le Ber, Ville Leinonen, Alejandro Tobon, Emma Lundberg, Astrid Lunkes, Henrike Maatz, Matthias Mann, Luca Marelli, Vera Matser, Paul M. Matthews, Fatima Mechta‐Grigoriou, Radhika Menon, A. Nielsen, Massimiliano Pagani, R. Jeroen Pasterkamp, Asla Pitkänen, Valentin Popescu, Cyril Pottier, Alain Puisieux, Rosa Rademakers, Dory Reiling, Orly Reiner, Daniel Remondini, Craig Ritchie, Jonathan D. Rohrer, Antoine-Emmanuel Saliba, Raquel Sánchez‐Valle, Amedeo Santosuosso, Arnold Sauter, Richard A. Scheltema, Philip Scheltens, Herbert B. Schiller, Anja Schneider, Philip Seibler, Kelly Sheehan‐Rooney, David J. Shields, Kristel Sleegers, August B. Smit, Kenneth G. C. Smith, Ilse Smolders, Matthis Synofzik, Wai Long Tam, Sarah A. Teichmann, Maria Thom, Margherita Y. Turco, Heleen M.M. van Beusekom, Rik Vandenberghe, Silvie Van den Hoecke, Ibo van de Poel, André van der Ven, Julie van der Zee, Jan van Lunzen, Geert Van Minnebruggen, Alexander van Oudenaarden, Wim Van Paesschen, John van Swieten, Remko van Vught, Matthijs Verhage, Patrik Verstreken, Carlo Emanuele Villa, Jörg Vogel, Christof von Kalle, Jörn Walter, Sarah Weckhuysen, Wilko Weichert, Louisa E. Wood, Anette‐Gabriele Ziegler, Frauke Zipp,

Cancer Genomics and Diagnostics

Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and clinical datasets will identify molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. The timely detection and interception of disease embedded in an ethical and patient-centred vision will be achieved through interactions across academia, hospitals, patient associations, health data management systems and industry. The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.