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Evaluation of Sarcopenia with F‐18 FDG PET/CT and relation with disease outcomes in patients with multiple myeloma

2020; Wiley; Volume: 29; Issue: 6 Linguagem: Inglês

10.1111/ecc.13318

1365-2354

Elif Gülsüm Ümıt, Ülkü Korkmaz, Mehmet Baysal, Sedanur Karaman Gülsaran, Volkan Baş, Ufuk Demirci, Hakkı Onur Kırkızlar, Gülay Durmuş Altun, Ahmet Muzaffer Demir,

Hematological disorders and diagnostics

European Journal of Cancer CareVolume 29, Issue 6 e13318 ORIGINAL ARTICLE Evaluation of Sarcopenia with F-18 FDG PET/CT and relation with disease outcomes in patients with multiple myeloma Elif G. Umit, Corresponding Author Elif G. Umit egugur@yahoo.com orcid.org/0000-0001-5589-3000 Department of Hematology, Faculty of Medicine, Trakya University, Edirne, Turkey Correspondence Elif G. Umit, Department of Hematology, Trakya University Faculty of Medicine, Balkan Yerleskesi, 22030 Edirne, Turkey. Email: egugur@yahoo.comSearch for more papers by this authorUlku Korkmaz, Ulku Korkmaz Department of Nuclear Medicine, Faculty of Medicine, Trakya University, Edirne, TurkeySearch for more papers by this authorMehmet Baysal, Mehmet Baysal orcid.org/0000-0001-7681-4623 Department of Hematology, Faculty of Medicine, Trakya University, Edirne, TurkeySearch for more papers by this authorSedanur Karaman Gulsaran, Sedanur Karaman Gulsaran Department of Hematology, Faculty of Medicine, Trakya University, Edirne, TurkeySearch for more papers by this authorVolkan Bas, Volkan Bas Department of Hematology, Faculty of Medicine, Trakya University, Edirne, TurkeySearch for more papers by this authorUfuk Demirci, Ufuk Demirci Department of Hematology, Faculty of Medicine, Trakya University, Edirne, TurkeySearch for more papers by this authorHakki Onur Kirkizlar, Hakki Onur Kirkizlar orcid.org/0000-0001-7523-8599 Department of Hematology, Faculty of Medicine, Trakya University, Edirne, TurkeySearch for more papers by this authorGulay Durmus Altun, Gulay Durmus Altun orcid.org/0000-0002-9773-5390 Department of Nuclear Medicine, Faculty of Medicine, Trakya University, Edirne, TurkeySearch for more papers by this authorAhmet Muzaffer Demir, Ahmet Muzaffer Demir orcid.org/0000-0002-2073-5405 Department of Hematology, Faculty of Medicine, Trakya University, Edirne, TurkeySearch for more papers by this author Elif G. Umit, Corresponding Author Elif G. Umit egugur@yahoo.com orcid.org/0000-0001-5589-3000 Department of Hematology, Faculty of Medicine, Trakya University, Edirne, Turkey Correspondence Elif G. Umit, Department of Hematology, Trakya University Faculty of Medicine, Balkan Yerleskesi, 22030 Edirne, Turkey. Email: egugur@yahoo.comSearch for more papers by this authorUlku Korkmaz, Ulku Korkmaz Department of Nuclear Medicine, Faculty of Medicine, Trakya University, Edirne, TurkeySearch for more papers by this authorMehmet Baysal, Mehmet Baysal orcid.org/0000-0001-7681-4623 Department of Hematology, Faculty of Medicine, Trakya University, Edirne, TurkeySearch for more papers by this authorSedanur Karaman Gulsaran, Sedanur Karaman Gulsaran Department of Hematology, Faculty of Medicine, Trakya University, Edirne, TurkeySearch for more papers by this authorVolkan Bas, Volkan Bas Department of Hematology, Faculty of Medicine, Trakya University, Edirne, TurkeySearch for more papers by this authorUfuk Demirci, Ufuk Demirci Department of Hematology, Faculty of Medicine, Trakya University, Edirne, TurkeySearch for more papers by this authorHakki Onur Kirkizlar, Hakki Onur Kirkizlar orcid.org/0000-0001-7523-8599 Department of Hematology, Faculty of Medicine, Trakya University, Edirne, TurkeySearch for more papers by this authorGulay Durmus Altun, Gulay Durmus Altun orcid.org/0000-0002-9773-5390 Department of Nuclear Medicine, Faculty of Medicine, Trakya University, Edirne, TurkeySearch for more papers by this authorAhmet Muzaffer Demir, Ahmet Muzaffer Demir orcid.org/0000-0002-2073-5405 Department of Hematology, Faculty of Medicine, Trakya University, Edirne, TurkeySearch for more papers by this author First published: 05 September 2020 https://doi.org/10.1111/ecc.13318Citations: 2Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Introduction Multiple myeloma (MM) is a potentially incurable haematological malignancy with devastating manifestations including lytic bone lesions leading to fractures and renal insufficiency. As a disease of patients with a mean age of 66 years, both the disease and the continuous efforts of treatments lead to frailty and devastation. From this stand point, we aimed to evaluate the development of muscle loss in MM patients and also with a new method of sarcopenia evaluation, F-18 FDG PET/CT. While used for bone disease routinely, this method brings a fresh perspective of metabolic quantitation of alteration of muscles which may be regarded as muscle quality. Materials and Methods Data and images of 105 patients with MM both before and after treatment were evaluated in a retrospective manner. Results Both female and male patients were observed to be effected after MM treatment in terms of lumbar and femoral muscle evaluations with CT. Metabolic evaluations confirmed a loss of quality in muscles in terms of metabolic volume and total lesion glycolysis. Conclusion Sarcopenia should be evaluated in every patient and regarded as a treatment target. FDG PET/CT is an easy and handy tool to assess muscle mass and quality as well as MM disease status. CONFLICT OF INTEREST All authors declare that they have no conflict of interest. All data are available for evaluation upon request and are full control of the corresponding author. Citing Literature Volume29, Issue6November 2020e13318 RelatedInformation