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BIBTEX RIS

Follow-Up Household Serosurvey in Northeast Brazil for Zika Virus: Sexual Contacts of Index Patients Have the Highest Risk for Seropositivity

2020; Oxford University Press; Volume: 223; Issue: 4 Linguagem: Inglês

10.1093/infdis/jiaa563

ISSN

1537-6613

Autores

Tereza Magalhães, Clarice Neuenschwander Lins de Morais, Iracema de Jesus Almeida Alves Jacques, Elisa de Almeida Neves Azevedo, Ana Maria de Brito, Priscilla V Lima, Gabriella M M Carvalho, Andreza R S Lima, Priscila M. S. Castanha, Marli Tenório Cordeiro, André Luiz Sá de Oliveira, Thomas Jaenisch, Molly M. Lamb, Ernesto T. A. Marques, Brian D. Foy,

Tópico(s)

Insect symbiosis and bacterial influences

Resumo

Zika virus (ZIKV) is a mosquito-borne virus that is also transmitted sexually; however, the epidemiological relevance of ZIKV sexual transmission in endemic regions is unclear.We performed a household-based serosurvey in Northeast Brazil to evaluate the differential exposure to ZIKV and chikungunya virus (CHIKV) among households. Individuals who participated in our previous arboviral disease cohort (indexes) were recontacted and enrolled, and their household members were newly enrolled.The relative risk of sexual partners being ZIKV-seropositive when living with a ZIKV-seropositive index participant was significantly higher, whereas this was not observed among nonsexual partners of the index. For CHIKV, both sexual and nonsexual partner household members living with a CHIKV-seropositive index had a significantly higher risk of being seropositive. In the nonindex-based dyadic and generalized linear mixed model analyses, the odds of sexual dyads having a concordant ZIKV plaque reduction neutralization test result was significantly higher. We have also analyzed retrospective clinical data according to the participants' exposure to ZIKV and CHIKV.Our data suggest that ZIKV sexual transmission may be a key factor for the high ZIKV seroprevalence among households in endemic areas and raises important questions about differential disease from the 2 modes of transmission.

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