Portal de Periódicos da CAPES

Fatty acid synthesis and cancer: Aberrant expression of the ACACA and ACACB genes increases the risk for cancer

2020; Elsevier BV; Volume: 26; Linguagem: Inglês

10.1016/j.mgene.2020.100798

2214-5400

Kasturi Bhattacharjee, Moumita Nath, Yashmin Choudhury,

Peroxisome Proliferator-Activated Receptors

Altered lipid metabolism is a characteristic feature of cancer cells. This systematic review assesses the risk for cancer development in association with the expression levels of the ACACA and ACACB genes which encode the rate limiting enzymes of fatty acid synthesis, acetyl-CoA carboxylase α (ACCα) and acetyl-CoA carboxylase β (ACCβ). The literature databases PubMed and Google Scholar were searched for variation in incidence of cancer depending on the expression of the ACACA and ACACB genes. In addition, related articles were retrieved from OMIM and Cochrane Library. Cohort studies, case control studies, studies using in vivo and in vitro models and randomized trials were evaluated to determine the risk for cancer associated with the altered expression of the genes. Overexpression of ACACA has been reported in cancers of the breast, lung, prostate, gliomas and colorectal cancer while low expression of ACACB has been reported in laryngeal squamous cell carcinoma, triple negative breast cancer, retinoblastoma, thyroid and melanoma. Increased expression of both ACACA and ACACB has been reported in hepatocellular carcinoma and glioblastoma. Various ACC-inhibitors with therapeutic potential have been developed, and several studies report the treatment of obesity related cancer by inhibiting ACC expression. Thus, ACC-inhibitors are potential therapeutic agents for effective treatment of cancer, especially obesity related cancers.