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Fertility Potential is Impaired in Boys with Bilateral Ascending Testes

2020; Lippincott Williams & Wilkins; Volume: 205; Issue: 2 Linguagem: Inglês

10.1097/ju.0000000000001350

1527-3792

Simone Hildorf, Erik Clasen‐Linde, Magdalena Fossum, Dina Cortes, Jørgen Thorup,

Sexual Differentiation and Disorders

No AccessJournal of UrologyPediatric Urology1 Feb 2021Fertility Potential is Impaired in Boys with Bilateral Ascending TestesThis article is commented on by the following:Editorial CommentEditorial Comment Simone Hildorf, Erik Clasen-Linde, Magdalena Fossum, Dina Cortes, and Jorgen Thorup Simone HildorfSimone Hildorf †Correspondence: Department of Pediatric Surgery, Surgical Clinic C, Section 4272, Copenhagen University Hospital Rigshospitalet, 9 Blegdamsvej, DK-2100Copenhagen, Denmark E-mail Address: [email protected] Department of Pediatric Surgery, Surgical Clinic C, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark More articles by this author , Erik Clasen-LindeErik Clasen-Linde Department of Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark More articles by this author , Magdalena FossumMagdalena Fossum Department of Pediatric Surgery, Surgical Clinic C, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden More articles by this author , Dina CortesDina Cortes Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Department of Pediatrics and Adolescence Medicine, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark More articles by this author , and Jorgen ThorupJorgen Thorup Department of Pediatric Surgery, Surgical Clinic C, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001350AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Ascending testes have been documented to be descended in the scrotum within the first year of life and then reascended. The aim of this study was to investigate to what extent the fertility potential was impaired in boys with such testes compared to the fertility potential of boys with late referral congenital cryptorchidism. Materials and Methods: A total of 153 consecutive boys underwent bilateral orchiopexy at age 2 to 7 years (median 3.9) between 2011 and 2018. Of the patients 67 were diagnosed with bilateral ascended testes and 86 with late referral bilateral congenital cryptorchidism. We assessed serum levels of inhibin B and gonadotropins and histological parameters, number of germ cells per tubule cross-section and number of type A dark (Ad) spermatogonia per tubule cross-section. All values were compared to our normal material. Results: Number of germ cells per tubule cross-section of boys with ascended testes (median 0.50, range 0 to 2.29) was not significantly higher compared to boys with congenital cryptorchidism (median 0.37, range 0 to 2.57; p=0.11). Mean number of germ cells per tubule cross-section was below normal range in 40 boys with ascending testes (60%) vs 57 boys with late referral congenital cryptorchidism (66%, p=0.40). Biopsies absent of Ad spermatogonia were noted in 31% of boys with ascending testes (21 of 67) vs 34% of boys with congenital cryptorchidism (29 of 86, p=0.76). Serum levels of inhibin B and gonadotropins did not differ between the 2 groups. Conclusions: The fertility potential of boys with bilateral ascended testes was impaired to almost the same level as that of boys with bilateral congenital cryptorchidism and should therefore be surgically corrected as soon as the diagnosis of ascended testes is settled. References 1. : The epidemiology of congenital cryptorchidism, testicular ascent and orchiopexy. J Urol 2003; 170: 2396. Link, Google Scholar 2. : The true incidence of cryptorchidism in Denmark. J Urol 2008; 179: 314. 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Google Scholar *Funded by the Novo Nordisk Foundation (Grant NNF SA170030576). © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byTanaka S (2020) This Month in Pediatric UrologyJournal of Urology, VOL. 205, NO. 2, (323-323), Online publication date: 1-Feb-2021.Related articlesJournal of Urology26 Nov 2020Editorial CommentJournal of Urology26 Nov 2020Editorial Comment Volume 205Issue 2February 2021Page: 586-594 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.Keywordspathologyinhibinsgerm cellscryptorchidismMetricsAuthor Information Simone Hildorf Department of Pediatric Surgery, Surgical Clinic C, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark †Correspondence: Department of Pediatric Surgery, Surgical Clinic C, Section 4272, Copenhagen University Hospital Rigshospitalet, 9 Blegdamsvej, DK-2100Copenhagen, Denmark E-mail Address: [email protected] More articles by this author Erik Clasen-Linde Department of Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark More articles by this author Magdalena Fossum Department of Pediatric Surgery, Surgical Clinic C, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden More articles by this author Dina Cortes Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Department of Pediatrics and Adolescence Medicine, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark More articles by this author Jorgen Thorup Department of Pediatric Surgery, Surgical Clinic C, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark More articles by this author Expand All *Funded by the Novo Nordisk Foundation (Grant NNF SA170030576). 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