Portal de Periódicos da CAPES

Golgi protein-73: A biomarker for assessing cirrhosis and prognosis of liver disease patients

2020; Baishideng Publishing Group; Volume: 26; Issue: 34 Linguagem: Inglês

10.3748/wjg.v26.i34.5130

2219-2840

Nikolaos Gatselis, Tamás Tornai, Zakera Shums, Kalliopi Zachou, Asterios Saitis, Stella Gabeta, Roger Albesa, Gary L. Norman, Mária Papp, George Ν. Dalekos,

Endoplasmic Reticulum Stress and Disease

Reliable biomarkers of cirrhosis, hepatocellular carcinoma (HCC), or progression of chronic liver diseases are missing. In this context, Golgi protein-73 (GP73) also called Golgi phosphoprotein-2, was originally defined as a resident Golgi type II transmembrane protein expressed in epithelial cells. As a result, GP73 expression was found primarily in biliary epithelial cells, with only slight detection in hepatocytes. However, in patients with acute or chronic liver diseases and especially in HCC, the expression of GP73 is significantly up-regulated in hepatocytes. So far, few studies have assessed GP73 as a diagnostic or prognostic marker of liver fibrosis and disease progression.