Electrochemical Decarboxylative N -Alkylation of Heterocycles
2020; American Chemical Society; Volume: 22; Issue: 19 Linguagem: Inglês
10.1021/acs.orglett.0c02799
ISSN1523-7060
AutoresTao Sheng, Hai‐Jun Zhang, Ming Shang, Chi He, Julien C. Vantourout, Phil S. Baran,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoAn operationally simple method to employ nonactivated carboxylic acids as alkylating agents in the N-alkylation of heterocycles is reported through an electrochemically driven anodic decarboxylative process. A wide substrate scope across a range of heterocycles is demonstrated along with a series of applications that significantly reduce the step count required to access such medicinally relevant structures.
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